Estriol-d2
Based on 1 Customer Validation
Estriol-d2 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.47%
- No. CAS: 53866-32-3
- Fòrmula: C18H22D2O3
- Peso molecular:290.39
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 53866-32-3
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Unlabeled Cas 50-27-1
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Appearance Solid
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Peso molecular 290.39
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Fòrmula C18H22D2O3
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Color White to off-white
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SMILES
OC1=C(C=C2C(CC[C@@]3([C@@]2(CC[C@]4([C@]3(C[C@H]([C@@H]4O)O)[H])C)[H])[H])=C1[2H])[2H]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 250 mg/mL (860.91 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (563 KB)
- English - EN (563 KB)
- Français - FR (563 KB)
- Deutsch - DE (563 KB)
- Norwegian - NO (563 KB)
- Español - ES (563 KB)
- Swedish - SV (563 KB)
- Italian - IT (563 KB)
- Korean - KR (563 KB)
- Portuguese - PT (563 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Morinaga, A., et al., Effects of sex hormones on Alzheimer's disease-associated beta-amyloid oligomer formation in vitro. Exp Neurol, 2011. 228(2): p. 298-302. [Content Brief]
[3]. Begum, M., et al., Neonatal estrogenic exposure suppresses PTEN-related endometrial carcinogenesis in recombinant mice. Lab Invest, 2006. 86(3): p. 286-96. [Content Brief]
[4]. Hewitt, S.C. and K.S. Korach, Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles. Environ Health Perspect, 2011. 119(1): p. 63-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4436 mL | 17.2182 mL | 34.4364 mL | 86.0911 mL |
| 5 mM | 0.6887 mL | 3.4436 mL | 6.8873 mL | 17.2182 mL | |
| 10 mM | 0.3444 mL | 1.7218 mL | 3.4436 mL | 8.6091 mL | |
| 15 mM | 0.2296 mL | 1.1479 mL | 2.2958 mL | 5.7394 mL | |
| 20 mM | 0.1722 mL | 0.8609 mL | 1.7218 mL | 4.3046 mL | |
| 25 mM | 0.1377 mL | 0.6887 mL | 1.3775 mL | 3.4436 mL | |
| 30 mM | 0.1148 mL | 0.5739 mL | 1.1479 mL | 2.8697 mL | |
| 40 mM | 0.0861 mL | 0.4305 mL | 0.8609 mL | 2.1523 mL | |
| 50 mM | 0.0689 mL | 0.3444 mL | 0.6887 mL | 1.7218 mL | |
| 60 mM | 0.0574 mL | 0.2870 mL | 0.5739 mL | 1.4349 mL | |
| 80 mM | 0.0430 mL | 0.2152 mL | 0.4305 mL | 1.0761 mL | |
| 100 mM | 0.0344 mL | 0.1722 mL | 0.3444 mL | 0.8609 mL |
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