50-27-1
Chemical Structure
Estriol
Synonym(s): Oestriol
- CAS No.: 50-27-1
- Formula:C18H24O3
- Molecular Weight:288.39
IUPAC Name: (8R,9S,13S,14S,16R,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,16,17-triol
InChIKey: PROQIPRRNZUXQM-ZXXIGWHRSA-N
SMILES: C[C@@]1([C@H]2O)[C@](C[C@H]2O)([H])[C@@](CCC3=C4C=CC(O)=C3)([H])[C@]4([H])CC1
Biological Activity: Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects[1][2][3].
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Estriol | 98.05% | Estriol (Oestriol), an orally active estrogen, is a ERα and ERβ agonist. Estriol is a potent GPR30 antagonist in estrogen receptor-negative breast cancer cells. Estriol can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Estriol has powerful proconvulsant effects. | ||||||||||||||||||||
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Estriol (Standard) | 99.59% | Estriol (Standard) is the analytical standard of Estriol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Estriol-d | Estriol-d is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. | |||||||||||||||||||||
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Estriol-13C3 | Estriol-13C3 is the 13C-labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. | |||||||||||||||||||||
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Estriol-d2 | 98.47% | Estriol-d2 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. | ||||||||||||||||||||
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Estriol-d3-1 | Estriol-d3-1 is the deuterium labeled Estriol. | |||||||||||||||||||||
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Estriol-d3 | 97.57% | Estriol-d3 is the deuterium labeled Estriol. Estriol is an antagonist of the G-protein coupled estrogen receptor in estrogen receptor-negative breast cancer cells. | ||||||||||||||||||||
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- [1]. Rosamaria Lappano, et al. Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Mol Cell Endocrinol. 2010 May 14;320(1-2):162-70. [Content Brief]
- [2]. Rainer Girgert, et al. Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17β-estradiol. BMC Cancer. 2014 Dec 11:14:935. [Content Brief]
- [3]. Aakifa Ahmad, et al. Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model. Neurol Sci. 2014 Oct;35(10):1561-6. [Content Brief]
