FAICAR
Based on 1 Customer Validation
FAICAR (5-Formamidoimidazole-4-carboxamide ribotide) is a purine nucleotide and the IMP cyclohydrolase substrate of Cryptococcus neoformans ATIC. It is a key intermediate in the de novo purine synthesis pathway. FAICAR can be used in studies related to Cryptococcus neoformans infection.
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- Pureza: 85.0%
- No. CAS: 13018-54-7
- Fòrmula: C10H15N4O9P
- Peso molecular:366.22
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Almacenamiento:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
FAICAR (0.005-0.3 mM) was used as substrate at 37°C, and recombinantly expressed C. neoformans ATIC exhibits IMP cyclohydrolase activity with a Km_app of 30 μM, Vmax of 8.6 U/mg, and kcat of 7.7 s−1[1].
FAICAR (0.1-4 μM) acts as a substrate for human AICAR transformylase-IMP cyclohydrolase's IMP cyclohydrolase domain, with a Ks of 0.87 μM at pH 7.4, and supports an IMP cyclohydrolase specific activity of 29.5 nmol IMP formed/min/μg protein at a concentration of 4 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 13018-54-7
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Appearance Solid
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Peso molecular 366.22
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Fòrmula C10H15N4O9P
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Color Dark purple to black
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SMILES
O=C(C1=C(NC=O)N([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)C=N1)N
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Synonyms
5-Formamidoimidazole-4-carboxamide ribotide
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Wizrah MSI, et al. AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J Biol Chem. 2022;298(10):102453. [Content Brief]
[2]. Szabados E, et al. Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography. Anal Biochem. 1994;221(2):401-404. [Content Brief]
[3]. Vergis JM, et al. Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase. Biochemistry. 2004;43(5):1184-1192. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FAICAR Related Classifications
HY-133157 Related Classifications
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