Arap3 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 Gene

Also Known as Drag1; Centd3; cnt-d3; E030006K04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 106952

Summary

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell Cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Arap3 Products (2)

mRNA Protein Name
NM_001205336.1 NP_001192265.1 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 2
NM_139206.2 NP_631945.2 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Referencias Source
NOT enables GTPase activator activity IDA
IDA: Inferred from direct assay
15546919 MGI
enables GTPase activator activity IDA
IDA: Inferred from direct assay
15546919 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15546919 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

  • ARF-GAP, RHO-GAP, ankyrin repeat and pleckstrin homology domains-containing protein 3

  • centaurin, delta 3

  • dual-specificity Rho- and Arf-GTPase activating protein 1

Arap3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Cross
Arap3 Q8R5G7 LYN Homo sapiens P07948
Anti Tag CoIP
15546919
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS00889 ARAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21483 Arap3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28001 Arap3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arap3 NCBI NCBI:64411