TLE3 - TLE family member 3, transcriptional corepressor Gene

Also Known as ESG; ESG3; GRG3; HsT18976

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7090

About TLE3

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:70,047,790-70,097,917 (from NCBI)

This gene has 24 transcripts (splice variants), 271 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

TLE3 Products (7)

mRNA Protein Name
NM_001105192.3 NP_001098662.1 transducin-like enhancer protein 3 isoform b
NM_001282979.2 NP_001269908.1 transducin-like enhancer protein 3 isoform e
NM_001282980.2 NP_001269909.1 transducin-like enhancer protein 3 isoform d
NM_001282981.2 NP_001269910.1 transducin-like enhancer protein 3 isoform f
NM_001282982.2 NP_001269911.1 transducin-like enhancer protein 3 isoform g
NM_005078.4 NP_005069.2 transducin-like enhancer protein 3 isoform a
NM_020908.3 NP_065959.1 transducin-like enhancer protein 3 isoform c

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
17577209 GOA
Cellular Component GO Annotation Evidence Referencias Source
part of beta-catenin-TCF complex IDA
IDA: Inferred from direct assay
28296634 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
22304967 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLE3 Protein Structure

TLE_N

TLE_N: Groucho/TLE N-terminal Q-rich domain (1 - 135)

WD40

WD40: WD domain, G-beta repeat (485 - 513)

WD40

WD40: WD domain, G-beta repeat (572 - 604)

WD40

WD40: WD domain, G-beta repeat (610 - 646)

WD40

WD40: WD domain, G-beta repeat (693 - 727)

WD40

WD40: WD domain, G-beta repeat (741 - 768)

  • 0
  • 200
  • 400
  • 600
  • 772 a.a.
Protein Preferred Names Protein Names

transducin-like enhancer protein 3

  • enhancer of split groucho 3

Recombinant TLE3 Proteins

Referencia número Nombre del producto Accession Pureza
HY-P76675 TLE3 Protein, Human (His) Q04726 (S484-Y772) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chromosome 1q21.1 Duplication Syndrome

  • 1q21.1 Microduplication Syndrome

  • Trisomy 1q21.1

  • 1q21.1 Duplication Syndrome

  • 1q21.1 Microduplication

  • 1q21.1 Duplication

  • Dup(1)(Q21.1)
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS14565 TLE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19963 Tle3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26465 Tle3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TLE3 MGD MGI:104634
Rattus norvegicus TLE3 RGD RGD:620292
Macaca mulatta TLE3 VGNC VGNC:78366
Felis catus TLE3 VGNC VGNC:66210
Canis familiaris TLE3 VGNC VGNC:47397
Bos taurus TLE3 VGNC VGNC:35891
Others TLE3 NCBI