HDAC8-IN-2
HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs.
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- No. CAS: 2824131-20-4
- Fòrmula: C21H16N2O5
- Peso molecular:376.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Schistosome |
hHDAC6 0.29 ± 0.0 μM (IC50) |
hHDAC8 0.32 ± 0.0 μM (IC50) |
hHDAC1 18.51 ± 1. μM (IC50) |
Chemical Information
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No. CAS 2824131-20-4
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Peso molecular 376.36
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Fòrmula C21H16N2O5
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SMILES
COC1=C(C=C(C=C1)C(NO)=O)NC(C2=C3OC4=C(C3=CC=C2)C=CC=C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC8-IN-2 Related Classifications
HY-144098 Related Classifications
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