MF-592
MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1064195-48-7
- Fòrmula: C34H33Cl2N3O6S
- Peso molecular:682.61
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
14 nM
Compound: 2f, MF-592
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Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
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[PMID: 21215624] |
| HEK293 | IC50 |
3 nM
Compound: 2; MF-592
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Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
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[PMID: 26764191] |
| HEK293 | IC50 |
3 nM
Compound: 2f, MF-592
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Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
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[PMID: 21215624] |
Chemical Information
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No. CAS 1064195-48-7
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Peso molecular 682.61
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Fòrmula C34H33Cl2N3O6S
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SMILES
O=S(C1=C(C=CC=C1Cl)Cl)(NC(NC2(CC2)CC3=CC=C(C(C)=C3)N(C4=O)CC5=C4C(OCC)=C6C=CC=CC6=C5OCC)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MF-592 Related Classifications
HY-118370 Related Classifications
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