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Referencia número: HY-145813

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MU1656

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies.

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No. CAS: 2766698-38-6
Fòrmula: C₃₂H₄₅N₇O₂
Peso molecular:559.75

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MU1656 Chemical Structure

No. CAS: 2766698-38-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Descripciòn
- IC₅₀ & Target
- Cellular Effect
Chemical Information
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Actividad biológica

Descripciòn

MU1656 is a potent and selective inhibitor of histone methyltransferase DOT1L, with an IC₅₀ of 2 nM. MU1656 can be used for the research of hematological malignancies^[1].

IC₅₀ & Target^[1]

DOT1L

2 nM (IC₅₀)

Ver todos los productos específicos de isoformas Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-13	EC₅₀	7.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MOLM-13 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
MV4-11	EC₅₀	1.7 μM Compound: (-)-53; MU1656	Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human MV4-11 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SK-N-MC	EC₅₀	8.8 μM Compound: (-)-53; MU1656	Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SK-N-MC cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]
SU-DHL-5	EC₅₀	9 μM Compound: (-)-53; MU1656	Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay Cytotoxicity against human SU-DHL-5 cells assessed as reduction of cell viability up to 10 uM incubated for 72 hrs by celltiter-glo assay	[PMID: 35302777]

Chemical Information

No. CAS 2766698-38-6
Peso molecular 559.75
Fòrmula C₃₂H₄₅N₇O₂
SMILES

O[C@H]1[C@@H](C[C@@H]([C@H]1O)CN([C@H]2C[C@H](C2)CCC(NC3=C4)=NC3=CC=C4C(C)(C)C)C(C)C)C5=CC=C6N5N=CN=C6N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Khirsariya P, et, al. Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides. J Med Chem. 2022 Apr 14;65(7):5701-5723. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
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- IC₅₀ & Target
Chemical Information
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MU1656

Ver todos los productos específicos de isoformas Histone Methyltransferase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

MU1656 Related Classifications

HY-145813 Related Classifications