PROTAC TEAD1/IAP degrader-1

Treatment of NCI-H2052 cells with PROTAC TEAD1/IAP degrader-1 for 20 h induces up to 55% degradation of HiBiT-TEAD1, with a DC₅₀ of 196 nM^[1].
Treatment with PROTAC TEAD1/IAP degrader-1 (0.01-10 μM; 20 h) induces up to 32% degradation of endogenous TEAD1 in NCI-H2052 cells with a DC₅₀ of 14 nM, and simultaneously induces up to 88% degradation of endogenous cIAP1 with a DC₅₀ of 270 nM^[1].
PROTAC TEAD1/IAP degrader-1 (0.001-10 μM; 144 h) inhibits the proliferation of ZL55, NCI-H226, NCI-H2052 and NCI-H520 cells, with IC₅₀ values of 2194 nM, 798 nM, 1375 nM and 2491 nM, respectively, and achieves nearly complete maximal inhibitory effect after 144 h of treatment^[1].
PROTAC TEAD1/IAP degrader-1 (0.001-10 μM; 48 h) reduces the transcriptional level of CTGF in ZL55, NCI-H226 and NCI-H2052 cells, with IC₅₀ values of 866 nM, 497 nM and 125 nM, respectively, after 48 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.