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United States

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Referencia número: HY-181987

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PSCdb01560

PSCdb01560 is a Dengue virus NS5 RNA-dependent RNA polymerase (RdRp) inhibitor. PSCdb01560 binds stably to the conserved allosteric N-pocket of the polymerase, maintains persistent interactions with key residues Arg729 and Arg737, and induces polymerase structure stabilization. PSCdb01560 can be used for the research of dengue virus infection.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₁₈H₂₀O₅
Peso molecular:316.35

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

PSCdb01560 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

IC₅₀ & Target

RNA Polymerase

Ver todos los productos específicos de isoformas DNA/RNA Synthesis :

In Vitro

PSCdb01560 forms a thermodynamically stable, tightly bound complex with dengue virus NS5 RdRp (PDB: 5K5M), exhibiting superior dynamic stability, minimal conformational drift, and a more favourable post-MD MM-GBSA binding free energy (-91.65 ± 4.02 kcal/mol) than the reference inhibitor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 316.35
Fòrmula C₁₈H₂₀O₅
SMILES

COC1=CC=C(C[C@H](O)C(C2=CC=C(OC)C=C2OC)=O)C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Alsaady IM, et al. Conformational dynamics and binding free energy analyses unveil a stable flavonoid inhibitor of dengue virus NS5 polymerase. Sci Rep. 2026;16(1):7761. Published 2026 Feb 7. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias

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PSCdb01560

Ver todos los productos específicos de isoformas DNA/RNA Synthesis