PSCdb01560
PSCdb01560 is a Dengue virus NS5 RNA-dependent RNA polymerase (RdRp) inhibitor. PSCdb01560 binds stably to the conserved allosteric N-pocket of the polymerase, maintains persistent interactions with key residues Arg729 and Arg737, and induces polymerase structure stabilization. PSCdb01560 can be used for the research of dengue virus infection.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C18H20O5
- Peso molecular:316.35
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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- Pureza y Documentación
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
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RNA Polymerase |
In Vitro
PSCdb01560 forms a thermodynamically stable, tightly bound complex with dengue virus NS5 RdRp (PDB: 5K5M), exhibiting superior dynamic stability, minimal conformational drift, and a more favourable post-MD MM-GBSA binding free energy (-91.65 ± 4.02 kcal/mol) than the reference inhibitor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Peso molecular 316.35
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Fòrmula C18H20O5
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SMILES
COC1=CC=C(C[C@H](O)C(C2=CC=C(OC)C=C2OC)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PSCdb01560 Related Classifications
HY-181987 Related Classifications
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