ADORA3 - adenosine A3 receptor Gene

Also Known as A3; TGPCR1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 100911796

About ADORA3

Primary_assembly 2: 193,388,713-193,392,357 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 272 orthologues, 3 paralogues and is associated with 3 phenotypes.

Summary

Enables G protein-coupled Adenosine Receptor activity. Involved in G protein-coupled receptor signaling pathway; regulation of norepinephrine secretion; and regulation of synaptic vesicle exocytosis. Located in presynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Orthologous to human ADORA3 (adenosine A3 receptor). [provided by Alliance of Genome Resources, Apr 2022]

ADORA3 Products (2)

mRNA Protein Name
NM_001302750.1 NP_001289679.1 adenosine receptor A3 isoform a
NM_001302751.1 NP_001289680.1 adenosine receptor A3 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled adenosine receptor activity IDA
IDA: Inferred from direct assay
1323836 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12475223 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
8987783 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
8987783 RGD
involved in regulation of norepinephrine secretion IMP
IMP: Inferred from mutant phenotype
16539684 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
8987783 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
8987783 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
14502093 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADORA3 Protein Structure

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (14 - 311)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (15 - 41)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (48 - 75)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (84 - 114)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (145 - 163)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (192 - 222)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (241 - 271)

7tmA_Adenosine_R_A3

7tmA_Adenosine_R_A3: cd15070 (279 - 304)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
Protein Preferred Names Protein Names

adenosine receptor A3

  • adenosine receptor A3-like

  • putative G-protein coupled receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00400 ADORA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00401 Adora3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00402 ADORA3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ADORA3 NCBI NCBI:140