Vrk3 - vaccinia related kinase 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 101568

Summary

Enables protein Phosphatase binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade and positive regulation of phosphoprotein Phosphatase activity. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Used to study autism spectrum disorder. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Vrk3 Products (1)

mRNA Protein Name
NM_133945.1 NP_598706.1 inactive serine/threonine-protein kinase VRK3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein phosphatase activator activity IPI
IPI: Inferred from physical interaction
18035061 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
18035061 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
18035061 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14645249 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive serine/threonine-protein kinase VRK3

  • serine/threonine-protein kinase VRK3

  • serine/threonine-protein pseudokinase VRK3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15704 VRK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22357 Vrk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28879 Vrk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vrk3 NCBI NCBI:51231