LPCAT3 - lysophosphatidylcholine acyltransferase 3 Gene

Also Known as C3F; LPCAT; LPSAT; OACT5; nessy; MBOAT5; LPLAT 5; LPLAT12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10162

About LPCAT3

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,976,185-7,018,476 (from NCBI)

This gene has 13 transcripts (splice variants), 205 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 59.9), small intestine (RPKM 50.5) and 25 other tissues.

Summary

Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

LPCAT3 Products (1)

mRNA Protein Name
NM_005768.6 NP_005759.4 lysophospholipid acyltransferase 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18195019 GOA
enables 1-acylglycerophosphocholine O-acyltransferase activity IMP
IMP: Inferred from mutant phenotype
22511767 GOA
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18772128 GOA
enables 1-acylglycerophosphoserine O-acyltransferase activity IDA
IDA: Inferred from direct assay
18195019 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphatidylcholine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18195019 GOA
involved in phosphatidylcholine acyl-chain remodeling IMP
IMP: Inferred from mutant phenotype
18782225 GOA
involved in phosphatidylethanolamine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18772128 GOA
involved in phosphatidylethanolamine acyl-chain remodeling IMP
IMP: Inferred from mutant phenotype
18782225 GOA
involved in phosphatidylserine acyl-chain remodeling IDA
IDA: Inferred from direct assay
18195019 GOA
involved in phosphatidylserine acyl-chain remodeling IMP
IMP: Inferred from mutant phenotype
18782225 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
18195019 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPCAT3 Protein Structure

MBOAT

MBOAT: MBOAT, membrane-bound O-acyltransferase family (128 - 437)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 487 a.a.
Protein Preferred Names Protein Names

lysophospholipid acyltransferase 5

  • 1-acylglycerophosphocholine O-acyltransferase

LPCAT3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86947 LPCAT3 Antibody (YA6640) WB, ICC/IF Human, Monkey

Related Diseases

Diseases Alias
Brachydactyly-Syndactyly Syndrome

  • BDSD

  • Brachydactyly-Syndactyly-Oligodactyly Syndrome

  • Brachydactyly-Syndactyly, Zhao Type

  • BDSDO
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-158790 (R)-HTS-3 Inhibitor 99.87% Unkown
HY-158790A (S)-HTS-3 / Unkown
HY-RS07766 LPCAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19065 Lpcat3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25555 Lpcat3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LPCAT3 VGNC VGNC:74405
Felis catus LPCAT3 VGNC VGNC:63266
Canis familiaris LPCAT3 VGNC VGNC:54322
Bos taurus LPCAT3 VGNC VGNC:30963
Rattus norvegicus LPCAT3 RGD RGD:1310223
Mus musculus LPCAT3 MGD MGI:1315211
Others LPCAT3 NCBI