B3GNT3 - UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Gene

Also Known as TMEM3; B3GN-T3; B3GNT-3; HP10328; B3GAL-T8; beta3Gn-T3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10331

About B3GNT3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,794,791-17,813,576 (from NCBI)

This gene has 4 transcripts (splice variants), 336 orthologues and 15 paralogues. Biased expression in colon (RPKM 28.2), stomach (RPKM 18.5) and 9 other tissues.

Summary

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking. [provided by RefSeq, Jul 2008]

B3GNT3 Products (1)

mRNA Protein Name
NM_014256.4 NP_055071.2 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
11042166 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in poly-N-acetyllactosamine biosynthetic process IDA
IDA: Inferred from direct assay
11042166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

B3GNT3 Protein Structure

Galactosyl_T

Galactosyl_T: Galactosyltransferase (122 - 311)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

  • UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01311 B3GNT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21825 B3gnt3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28342 B3gnt3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta B3GNT3 VGNC VGNC:104703
Bos taurus B3GNT3 VGNC VGNC:26379
Rattus norvegicus B3GNT3 RGD RGD:1305151
Canis familiaris B3GNT3 VGNC VGNC:38342
Felis catus B3GNT3 VGNC VGNC:102004
Mus musculus B3GNT3 MGD MGI:2152535
Others B3GNT3 NCBI