ANAPC10 - anaphase promoting complex subunit 10 Gene

Also Known as DOC1; APC10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10393

About ANAPC10

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:144,994,575-145,098,571 (from NCBI)

This gene has 18 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.0) and 25 other tissues.

Summary

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein Ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from Mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

ANAPC10 Products (9)

mRNA	Protein	Name
NM_001256706.2	NP_001243635.1	anaphase-promoting complex subunit 10 isoform 1
NM_001256707.2	NP_001243636.1	anaphase-promoting complex subunit 10 isoform 1
NM_001256708.2	NP_001243637.1	anaphase-promoting complex subunit 10 isoform 1
NM_001256709.2	NP_001243638.1	anaphase-promoting complex subunit 10 isoform 2
NM_001256710.2	NP_001243639.1	anaphase-promoting complex subunit 10 isoform 3
NM_001256711.2	NP_001243640.1	anaphase-promoting complex subunit 10 isoform 3
NM_001256712.2	NP_001243641.1	anaphase-promoting complex subunit 10 isoform 4
NM_001318367.2	NP_001305296.1	anaphase-promoting complex subunit 10 isoform 5
NM_014885.5	NP_055700.2	anaphase-promoting complex subunit 10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	34595750	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	10318877	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC10 Protein Structure

ANAPC10

0
100
185 a.a.

Protein Preferred Names	Protein Names
anaphase-promoting complex subunit 10	cyclosome subunit 10

ANAPC10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84877	ANAPC10 Antibody (YA4574)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84877A	ANAPC10 Antibody (YA4574)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Auditory System Cancer	Ear Neoplasms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00678	ANAPC10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ANAPC10	VGNC	VGNC:25880
Macaca mulatta	ANAPC10	VGNC	VGNC:69682
Felis catus	ANAPC10	VGNC	VGNC:78452
Rattus norvegicus	ANAPC10	RGD	RGD:1308936
Mus musculus	ANAPC10	MGD	MGI:1916249
Canis familiaris	ANAPC10	VGNC	VGNC:37845