2. Gene
  3. ANAPC10 - anaphase promoting complex subunit 10 Gene

ANAPC10 - anaphase promoting complex subunit 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DOC1; APC10

Gene ID: 10393 | Gene type: protein coding

About ANAPC10

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:144,994,575-145,098,571 (from NCBI)

This gene has 18 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.0) and 25 other tissues.

Summary

ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]

ANAPC10 Products(9)

mRNA Protein Name
NM_001256706.2 NP_001243635.1 anaphase-promoting complex subunit 10 isoform 1
NM_001256707.2 NP_001243636.1 anaphase-promoting complex subunit 10 isoform 1
NM_001256708.2 NP_001243637.1 anaphase-promoting complex subunit 10 isoform 1
NM_001256709.2 NP_001243638.1 anaphase-promoting complex subunit 10 isoform 2
NM_001256710.2 NP_001243639.1 anaphase-promoting complex subunit 10 isoform 3
NM_001256711.2 NP_001243640.1 anaphase-promoting complex subunit 10 isoform 3
NM_001256712.2 NP_001243641.1 anaphase-promoting complex subunit 10 isoform 4
NM_001318367.2 NP_001305296.1 anaphase-promoting complex subunit 10 isoform 5
NM_014885.5 NP_055700.2 anaphase-promoting complex subunit 10 isoform 1

ANAPC10 Protein Structure

ANAPC10

ANAPC10: Anaphase-promoting complex, subunit 10 (APC10) (4 - 183)

  • 0
  • 100
  • 185 a.a.
Protein Preferred Names Protein Names

anaphase-promoting complex subunit 10

cyclosome subunit 10

Related Diseases

Diseases Alias
Auditory System Cancer

Ear Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00678 ANAPC10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ANAPC10 VGNC VGNC:25880
Macaca mulatta ANAPC10 VGNC VGNC:69682
Felis catus ANAPC10 VGNC VGNC:78452
Rattus norvegicus ANAPC10 RGD RGD:1308936
Mus musculus ANAPC10 MGD MGI:1916249
Canis familiaris ANAPC10 VGNC VGNC:37845