Espl1 - extra spindle pole bodies 1, separase Gene

Also Known as SSE; Cerp; ESP1; PRCE

Species: Mus musculus

Gene Type: protein coding
Gene ID: 105988

Summary

Enables cysteine-type peptidase activity. Acts upstream of or within homologous chromosome segregation; meiotic spindle organization; and mitotic sister chromatid segregation. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Used to study breast Cancer. Orthologous to human ESPL1 (extra spindle pole bodies like 1, Separase). [provided by Alliance of Genome Resources, Apr 2022]

Espl1 Products (2)

mRNA Protein Name
NM_001014976.2 NP_001014976.1 separin
NM_001356312.1 NP_001343241.1 separin

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
23975099 MGI
enables peptidase activity IDA
IDA: Inferred from direct assay
19625504 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromosome segregation IGI
IGI: Inferred from genetic interaction
16533945 MGI
acts upstream of or within homologous chromosome segregation IMP
IMP: Inferred from mutant phenotype
14561405 MGI
acts upstream of or within meiosis I IMP
IMP: Inferred from mutant phenotype
14561405 MGI
acts upstream of or within meiotic spindle organization IMP
IMP: Inferred from mutant phenotype
14561405 MGI
acts upstream of or within mitotic cell cycle IGI
IGI: Inferred from genetic interaction
23975099 MGI
acts upstream of or within mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
16533945 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

separin

  • Cut1/ESP1 related protein

  • caspase-like protein ESPL1

  • extra spindle poles-like 1 protein

  • separase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04527 ESPL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19433 Espl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25924 Espl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Espl1 NCBI NCBI:9700