ARPP21 - cAMP regulated phosphoprotein 21 Gene

Also Known as RCS; TARPP; R3HDM3; ARPP-21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10777

About ARPP21

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:35,638,853-35,794,486 (from NCBI)

This gene has 36 transcripts (splice variants), 134 orthologues and 2 paralogues. Biased expression in brain (RPKM 4.3) and esophagus (RPKM 0.1).

Summary

This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

ARPP21 Products (49)

mRNA Protein Name
NM_001025068.1 NP_001020239.1 cAMP-regulated phosphoprotein 21 isoform 2
NM_001025069.1 NP_001020240.1 cAMP-regulated phosphoprotein 21 isoform 2
NM_001267616.2 NP_001254545.1 cAMP-regulated phosphoprotein 21 isoform 2
NM_001267617.2 NP_001254546.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001267618.2 NP_001254547.1 cAMP-regulated phosphoprotein 21 isoform 2
NM_001267619.2 NP_001254548.1 cAMP-regulated phosphoprotein 21 isoform 4
NM_001385484.1 NP_001372413.1 cAMP-regulated phosphoprotein 21 isoform 4
NM_001385485.1 NP_001372414.1 cAMP-regulated phosphoprotein 21 isoform 4
NM_001385486.1 NP_001372415.1 cAMP-regulated phosphoprotein 21 isoform 4
NM_001385487.1 NP_001372416.1 cAMP-regulated phosphoprotein 21 isoform 4
NM_001385488.1 NP_001372417.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385489.1 NP_001372418.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385490.1 NP_001372419.1 cAMP-regulated phosphoprotein 21 isoform 6
NM_001385491.1 NP_001372420.1 cAMP-regulated phosphoprotein 21 isoform 14
NM_001385492.1 NP_001372421.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385495.1 NP_001372424.1 cAMP-regulated phosphoprotein 21 isoform 7
NM_001385496.1 NP_001372425.1 cAMP-regulated phosphoprotein 21 isoform 13
NM_001385497.1 NP_001372426.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385517.1 NP_001372446.1 cAMP-regulated phosphoprotein 21 isoform 15
NM_001385536.1 NP_001372465.1 cAMP-regulated phosphoprotein 21 isoform 9
NM_001385556.1 NP_001372485.1 cAMP-regulated phosphoprotein 21 isoform 12
NM_001385558.1 NP_001372487.1 cAMP-regulated phosphoprotein 21 isoform 8
NM_001385562.1 NP_001372491.1 cAMP-regulated phosphoprotein 21 isoform 6
NM_001385563.1 NP_001372492.1 cAMP-regulated phosphoprotein 21 isoform 10
NM_001385564.1 NP_001372493.1 cAMP-regulated phosphoprotein 21 isoform 4
NM_001385565.1 NP_001372494.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385566.1 NP_001372495.1 cAMP-regulated phosphoprotein 21 isoform 11
NM_001385567.1 NP_001372496.1 cAMP-regulated phosphoprotein 21 isoform 8
NM_001385573.1 NP_001372502.1 cAMP-regulated phosphoprotein 21 isoform 10
NM_001385574.1 NP_001372503.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385576.1 NP_001372505.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385577.1 NP_001372506.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385578.1 NP_001372507.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385580.1 NP_001372509.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385581.1 NP_001372510.1 cAMP-regulated phosphoprotein 21 isoform 3
NM_001385582.1 NP_001372511.1 cAMP-regulated phosphoprotein 21 isoform 10
NM_001385584.1 NP_001372513.1 cAMP-regulated phosphoprotein 21 isoform 10
NM_001385585.1 NP_001372514.1 cAMP-regulated phosphoprotein 21 isoform 9
NM_001385587.1 NP_001372516.1 cAMP-regulated phosphoprotein 21 isoform 4
NM_001385588.2 NP_001372517.1 cAMP-regulated phosphoprotein 21 isoform 4
NM_001385589.1 NP_001372518.1 cAMP-regulated phosphoprotein 21 isoform 8
NM_001385590.1 NP_001372519.1 cAMP-regulated phosphoprotein 21 isoform 8
NM_001385591.1 NP_001372520.1 cAMP-regulated phosphoprotein 21 isoform 7
NM_001385592.1 NP_001372521.1 cAMP-regulated phosphoprotein 21 isoform 6
NM_001385593.1 NP_001372522.1 cAMP-regulated phosphoprotein 21 isoform 16
NM_001385594.1 NP_001372523.1 cAMP-regulated phosphoprotein 21 isoform 6
NM_001385595.1 NP_001372524.1 cAMP-regulated phosphoprotein 21 isoform 5
NM_016300.5 NP_057384.2 cAMP-regulated phosphoprotein 21 isoform 1
NM_198399.2 NP_938409.1 cAMP-regulated phosphoprotein 21 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARPP21 Protein Structure

R3H

R3H: R3H domain (164 - 224)

SUZ

SUZ: SUZ domain (245 - 299)

  • 0
  • 200
  • 400
  • 600
  • 812 a.a.
Protein Preferred Names Protein Names

cAMP-regulated phosphoprotein 21

  • R3H domain containing 3

ARPP21 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89859 ARPP-21 Antibody (YA9203) WB, ICC/IF, IF-Tissue, IP, ELISA human

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Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01026 ARPP21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARPP21 RGD RGD:1593239
Mus musculus ARPP21 MGD MGI:107562
Bos taurus ARPP21 VGNC VGNC:58588
Canis familiaris ARPP21 VGNC VGNC:38134
Felis catus ARPP21 VGNC VGNC:59942
Macaca mulatta ARPP21 VGNC VGNC:69845