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Grm3 - glutamate receptor, metabotropic 3 Gene

Also Known as mGlu3; Gprc1c; mGluR3; 0710001G23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 108069

About Grm3

Chromosome 5: 9,535,541-9,775,170 reverse strand.GRCm39:CM000998.3

This gene has 1 transcript (splice variant), 215 orthologues, 7 paralogues and is associated with 22 phenotypes. Biased expression in cortex adult (RPKM 11.5), frontal lobe adult (RPKM 9.3) and 4 other tissues.

Summary

Enables Calcium Channel regulator activity and group II metabotropic glutamate receptor activity. Acts upstream of or within gene expression. Located in several cellular components, including glutamatergic synapse; postsynaptic density; and synaptic membrane. Is integral component of postsynaptic membrane. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Orthologous to human GRM3 (glutamate metabotropic receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Grm3 Products (1)

mRNA	Protein	Name
NM_181850.2	NP_862898.1	metabotropic glutamate receptor 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium channel regulator activity	IDA IDA: Inferred from direct assay	7965099	MGI
enables group II metabotropic glutamate receptor activity	IDA IDA: Inferred from direct assay	7965099	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to stress	IDA IDA: Inferred from direct assay	29024663	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	18720515	MGI
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	31735403	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	31735403	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	11591452	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	11591452	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	31735403	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11591452	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	12074840	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11591452	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	15579147	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	11591452	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	11591452	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	11591452	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	11591452	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm3 Protein Structure

PBP1_mGluR_groupII

NCD3G

7tmC_mGluR3

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200
400
600
800
879 a.a.

Protein Preferred Names	Protein Names
metabotropic glutamate receptor 3	G protein-coupled receptor, family C, group 1, member C

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05825	GRM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05826	Grm3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05827	Grm3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grm3	NCBI	NCBI:2913