CEACAM4 - CEA cell adhesion molecule 4 Gene

Also Known as NCA; CGM7; CGM7_HUMAN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1089

About CEACAM4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,613,436-41,627,074 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 474 orthologues and 24 paralogues. Biased expression in bone marrow (RPKM 8.4), spleen (RPKM 4.0) and 4 other tissues.

Summary

Involved in phagocytosis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

CEACAM4 Products (4)

mRNA Protein Name
NM_001362492.2 NP_001349421.1 carcinoembryonic antigen-related cell adhesion molecule 4 isoform 2 precursor
NM_001362493.2 NP_001349422.1 carcinoembryonic antigen-related cell adhesion molecule 4 isoform 3
NM_001362495.2 NP_001349424.1 carcinoembryonic antigen-related cell adhesion molecule 4 isoform 4 precursor
NM_001817.4 NP_001808.2 carcinoembryonic antigen-related cell adhesion molecule 4 isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in phagocytosis IDA
IDA: Inferred from direct assay
25567962 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEACAM4 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (42 - 140)

  • 0
  • 100
  • 200
  • 244 a.a.
Protein Preferred Names Protein Names

carcinoembryonic antigen-related cell adhesion molecule 4

  • Nonspecific cross-reacting antigen (NCA)

Related Diseases

Diseases Alias
Ovarian Mucinous Adenocarcinoma

  • Mucinous Carcinoma Of Ovary
Ophthalmia Neonatorum

  • Gonococcal Conjunctivitis

  • Gonococcal Ophthalmia Neonatorum

  • Neonatal Conjunctivitis
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02440 CEACAM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CEACAM4 RGD RGD:708435
Others CEACAM4 NCBI