Actn1 - actinin, alpha 1 Gene

Also Known as Actn1a; 3110023F10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109711

Summary

Enables cytoskeletal protein binding activity; Integrin binding activity; and protein homodimerization activity. Involved in actin filament bundle assembly. Located in several cellular components, including Z disc; fascia adherens; and ruffle. Colocalizes with stress fiber. Is expressed in brain; heart; and testis. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Actn1 Products (4)

mRNA Protein Name
NM_001346669.2 NP_001333598.1 alpha-actinin-1 isoform 2
NM_001379075.1 NP_001366004.1 alpha-actinin-1 isoform 3
NM_001379076.1 NP_001366005.1 alpha-actinin-1 isoform 4
NM_134156.3 NP_598917.1 alpha-actinin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
11223950 MGI
enables integrin binding IPI
IPI: Inferred from physical interaction
11223950 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12223541 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
11223950 MGI
enables vinculin binding IDA
IDA: Inferred from direct assay
11223950 MGI
Biological Process GO Annotation Evidence References Source
involved in actin filament bundle assembly IDA
IDA: Inferred from direct assay
16043482 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
15665106 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in fascia adherens IDA
IDA: Inferred from direct assay
11732910 MGI
located in ruffle IDA
IDA: Inferred from direct assay
17298598 MGI
located in sarcomere IDA
IDA: Inferred from direct assay
24364879 MGI
colocalizes with stress fiber IDA
IDA: Inferred from direct assay
23890175 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-actinin-1

  • F-actin cross-linking protein

  • alpha actinin 1a

  • non-muscle alpha-actinin-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1728 Super-TDU (1-31) Inhibitor / Unkown
HY-P1728A Super-TDU (1-31) TFA Inhibitor 99.27% Unkown
HY-RS00223 ACTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17075 Actn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23519 Actn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Actn1 NCBI NCBI:87