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CHI3L2 - chitinase 3 like 2 Gene

Also Known as CHIL2; YKL39; YKL-39

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1117

About CHI3L2

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,227,659-111,243,440 (from NCBI)

This gene has 17 transcripts (splice variants), 99 orthologues and 6 paralogues. Biased expression in appendix (RPKM 55.9), salivary gland (RPKM 27.1) and 11 other tissues.

Summary

The protein encoded by this gene is similar to Bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CHI3L2 Products (3)

mRNA	Protein	Name
NM_001025197.1	NP_001020368.1	chitinase-3-like protein 2 isoform b
NM_001025199.2	NP_001020370.1	chitinase-3-like protein 2 isoform c
NM_004000.3	NP_003991.2	chitinase-3-like protein 2 isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables chitin binding	IDA IDA: Inferred from direct assay	22742450	GOA
NOT enables chitinase activity	IDA IDA: Inferred from direct assay	22742450	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHI3L2 Protein Structure

Glyco_hydro_18

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
chitinase-3-like protein 2	chondrocyte protein 39

Recombinant CHI3L2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7816	CHI3L2 Protein, Human (HEK293, His)	AAH11460.1 (Y27-L390)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02627	CHI3L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown