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SLC2A6 - solute carrier family 2 member 6 Gene

Also Known as GLUT6; GLUT9; HSA011372

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11182

About SLC2A6

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,471,094-133,479,099 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 295 orthologues and 13 paralogues. Broad expression in spleen (RPKM 3.2), appendix (RPKM 3.1) and 22 other tissues.

Summary

Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]

SLC2A6 Products (2)

mRNA	Protein	Name
NM_001145099.2	NP_001138571.1	solute carrier family 2, facilitated glucose transporter member 6 isoform 2
NM_017585.4	NP_060055.2	solute carrier family 2, facilitated glucose transporter member 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables D-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	30431159	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in D-glucose transmembrane transport	IDA IDA: Inferred from direct assay	30431159	GOA
involved in regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	30431159	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in lysosomal membrane	IDA IDA: Inferred from direct assay	30431159	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC2A6 Protein Structure

Sugar_tr

0
100
200
300
400
507 a.a.

Protein Preferred Names	Protein Names
solute carrier family 2, facilitated glucose transporter member 6	GLUT-6

Related Diseases

Diseases	Alias
Endometrial Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of Endometrium
Testis Seminoma	Seminoma Of Testis Seminoma Testis Testicular Seminoma Pure Seminoma
Arterial Tortuosity Syndrome	Arterial Tortuosity Ats ATORS Tortuosity, Arterial, Syndrome
Fanconi Syndrome	Infantile Nephropathic Cystinosis Adult Fanconi Syndrome Congenital Fanconi Syndrome De Toni-Fanconi Syndrome Fanconi-De Toni Syndrome Lignac-Fanconi Syndrome Fanconi Renotubular Syndrome Primary Fanconi Renotubular Syndrome De Toni-Debre-Fanconi Syndrome Adult Fanconi Anemia Detoni Fanconi Syndrome Fanconi-De-Toni Syndrome Primary Fanconi Syndrome Detoni-Debre-Fanconi Syndrome Primary Fanconi Renal Syndrome Fanconi Anemia Cystinosis, Infantile Nephropathic Fanconi-Bickel Syndrome Renal Fanconi Syndrome Lowe-Bickel Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13175	SLC2A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC2A6	VGNC	VGNC:82238
Rattus norvegicus	SLC2A6	RGD	RGD:1309317
Mus musculus	SLC2A6	MGD	MGI:2443286
Felis catus	SLC2A6	VGNC	VGNC:65305
Canis familiaris	SLC2A6	VGNC	VGNC:46343
Bos taurus	SLC2A6	VGNC	VGNC:34802
Others	SLC2A6	NCBI