AKAP10 - A-kinase anchoring protein 10 Gene

Also Known as PRKA10; AKAP-10; D-AKAP2; D-AKAP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11216

About AKAP10

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,904,302-19,977,828 (from NCBI)

This gene has 11 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in thyroid (RPKM 7.7), testis (RPKM 7.4) and 25 other tissues.

Summary

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]

AKAP10 Products (2)

mRNA Protein Name
NM_001330152.2 NP_001317081.1 A-kinase anchor protein 10, mitochondrial isoform 2
NM_007202.4 NP_009133.2 A-kinase anchor protein 10, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20159461 GOA
enables protein kinase A binding IPI
IPI: Inferred from physical interaction
25097019 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
25097019 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKAP10 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (126 - 367)

RGS

RGS: Regulator of G protein signaling domain (385 - 504)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
Protein Preferred Names Protein Names

A-kinase anchor protein 10, mitochondrial

  • A kinase (PRKA) anchor protein 10

Related Diseases

Diseases Alias
Long Qt Syndrome 1

  • Romano-Ward Syndrome

  • LQT1

  • Ward-Romano Syndrome

  • Rws

  • Ventricular Fibrillation With Prolonged Qt Interval

  • Wrs

  • Long Qt Syndrome 1, Acquired, Susceptibility To

  • Long Qt Syndrome 1, Acquired

  • Romano-Ward Long Qt Syndrome

  • Long Qt Syndrome Type 1

  • Long Qt Syndrome-1

  • Acquired Susceptibility To Long Qt Syndrome 1

  • Qt Syndrome, Long, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00513 AKAP10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AKAP10 VGNC VGNC:37752
Felis catus AKAP10 VGNC VGNC:59711
Rattus norvegicus AKAP10 RGD RGD:1308869
Macaca mulatta AKAP10 VGNC VGNC:69764
Bos taurus AKAP10 VGNC VGNC:25780
Mus musculus AKAP10 MGD MGI:1890218
Others AKAP10 NCBI