Egln1 - egl-9 family hypoxia-inducible factor 1 Gene

Also Known as Phd2; HPH-2; ORF13; SM-20; C1orf12; HIF-PH2; Hif-p4h-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 112405

Summary

Predicted to enable enzyme binding activity; ferrous iron binding activity; and peptidyl-proline 4-dioxygenase activity. Involved in several processes, including cellular iron ion homeostasis; regulation of angiogenesis; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Acts upstream of or within heart morphogenesis and labyrinthine layer development. Located in glutamatergic synapse. Is active in postsynaptic density. Is expressed in brain; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Egln1 Products (2)

mRNA	Protein	Name
NM_001363475.2	NP_001350404.1	egl nine homolog 1 isoform 2
NM_053207.3	NP_444437.2	egl nine homolog 1 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	16966370	MGI
acts upstream of or within heart trabecula formation	IMP IMP: Inferred from mutant phenotype	16966370	MGI
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	26818499	MGI
acts upstream of or within labyrinthine layer development	IMP IMP: Inferred from mutant phenotype	16966370	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	26818499	MGI
involved in regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18500250	MGI
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	26972007	MGI
involved in regulation of modification of postsynaptic structure	IEP IEP: Inferred from expression pattern	26972007	MGI
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	26972007	MGI
involved in regulation protein catabolic process at postsynapse	IDA IDA: Inferred from direct assay	26972007	MGI
involved in regulation protein catabolic process at postsynapse	IEP IEP: Inferred from expression pattern	26972007	MGI
involved in regulation protein catabolic process at postsynapse	IMP IMP: Inferred from mutant phenotype	26972007	MGI
acts upstream of or within ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	16966370	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26972007	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	26972007	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26972007	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	26972007	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	26972007	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
egl nine homolog 1	HIF-prolyl hydroxylase 2 hypoxia-inducible factor prolyl hydroxylase 2 prolyl hydroxylase domain-containing protein 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04212	EGLN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18812	Egln1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25302	Egln1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Egln1	NCBI	NCBI:54583