Egln3 - egl-9 family hypoxia-inducible factor 3 Gene

Also Known as Phd3; SM-20; Hif-p4h-3; 2610021G09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 112407

Summary

Enables peptidyl-proline dioxygenase activity. Involved in regulation of cell population proliferation and regulation of neuron apoptotic process. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gallbladder; genitourinary system; gut; skeletal musculature; and somite. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Egln3 Products (1)

mRNA Protein Name
NM_028133.2 NP_082409.2 prolyl hydroxylase EGLN3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables peptidyl-proline dioxygenase activity IDA
IDA: Inferred from direct assay
24030251 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18332118 MGI
involved in regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18332118 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl hydroxylase EGLN3

  • HIF-PH3

  • HIF-prolyl hydroxylase 3

  • HPH-3

  • hypoxia-inducible factor prolyl hydroxylase 3

  • prolyl hydroxylase domain-containing protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168533 ZG-2305 Inhibitor 98.60% Unkown
HY-RS04214 EGLN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20396 Egln3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26905 Egln3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Egln3 NCBI NCBI:112399