PTGDR2 - prostaglandin D2 receptor 2 Gene

Also Known as DP2; DL1R; CD294; CRTH2; GPR44

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11251

About PTGDR2

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,850,933-60,855,950 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 17 paralogues. Broad expression in stomach (RPKM 4.7), colon (RPKM 3.6) and 21 other tissues.

Summary

This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]

PTGDR2 Products (1)

mRNA Protein Name
NM_004778.3 NP_004769.2 prostaglandin D2 receptor 2

PTGDR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 304)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

prostaglandin D2 receptor 2

  • G-protein coupled receptor 44

  • chemoattractant receptor homologous molecule expressed on T helper type 2 cells

  • chemoattractant receptor-homologous molecule expressed on TH2 cells

  • putative G-protein coupled receptor 44

Related Diseases

Diseases Alias
Contact Blepharoconjunctivitis
Dermatitis, Atopic, 5

  • ATOD5

  • Atopic Dermatitis 5

  • Dermatitis, Atopic, Susceptibility To, 5

  • Dermatitis, Atopic 5
Nasal Cavity Disease

  • Disorder Of Nasal Cavity
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Contact Dermatitis

  • Contact Dermatitis/Eczema

  • Contact Eczema

  • Dermatitis Venenata

  • Dermatitis, Venenata

  • Dermatitis Contact

  • Dermatitis, Contact
Apricot Allergy

  • Prunus Armeniaca Fruit Allergy
Chronic Rhinitis

  • Rhinitis - Chronic

  • Chronic Rhinitis Nos

  • Rhinitis

  • Rhinitis Nos
T2-High Asthma

  • Type 2 High Endotype
Allergic Contact Dermatitis

  • Dermatitis, Allergic Contact

  • Contact Dermatitis, Allergic

  • Dermatitis Allergic Contact

  • Allergic Contact Eczema

  • Acd - [Allergic Contact Dermatitis]

  • Allergic Contact Dermatitis, Unspecified Cause

  • Allergic Dermatitis

  • Allergic Eczema

  • Allergy Dermatitis

  • Allergy Eczema

  • Allergic Contact Eczema Due To Clothing Or Footwear

  • Perfume Allergic Contact Dermatitis

  • Allergic Contact Dermatitis Due To Cosmetics

  • Allergic Contact Eczema Due To Cosmetics Or Fragrances

  • Allergic Contact Eczema Due To Dental Materials

  • Allergic Contact Eczema Due To Food Flavours Or Additives

  • Allergic Contact Eczema Due To Hairdressing Products

  • Allergic Contact Eczema Due To Metals Or Metal Salts

  • Allergic Contact Eczema Due To Proteins

  • Allergic Contact Eczema Due To Plastics Or Resin Systems

  • Allergic Contact Eczema Due To Preservatives Or Biocides

  • Allergic Contact Eczema Due To Rubber Chemicals

  • Rubber Dermatitis

  • Allergic Contact Eczema Due To Systemic Medicaments

  • Allergic Contact Eczema Due To Topical Medicaments

  • Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Chronic Asthma
Folliculitis
Diclofenac Allergy

  • Voltaren Allergy
T2-Low Asthma

  • Type 2 Low Endotype
Respiratory Allergy

  • Airway Allergy
Bronchial Disease

  • Bronchial Diseases

  • Bronchial Disorders

  • Bronchial Spasm
Pollen Allergy

  • Hay Fever
Spherocytosis, Type 2

  • Hereditary Spherocytosis Type 2

  • SPH2

  • Spherocytosis, Hereditary, 2

  • Hs2

  • Hereditary Spherocytosis 2

  • Spherocytosis 2

  • Spherocytosis, Type 2, Autosomal Dominant
Pneumothorax, Primary Spontaneous

  • Primary Spontaneous Pneumothorax

  • Spontaneous Pneumothorax

  • Familial Spontaneous Pneumothorax

  • PSP

  • Pneumothorax
Nose Disease

  • Nose Diseases

  • Disorder Of The Nose

  • Nasal Disorder

  • Abnormality Of The Nose
Esophagitis, Eosinophilic, 1

  • Eosinophilic Esophagitis

  • EOE1

  • Esophagitis, Eosinophilic

  • Ee
Common Cold

  • Acute Coryza

  • Acute Nasopharyngitis

  • Acute Rhinitis

  • Acute Viral Rhinopharyngitis

  • Nasopharyngitis - Acute

  • Nasopharyngitis, Acute

  • Rhino-Sinusitis

  • Rhinosinusitis

  • Common Colds

  • Acute Infective Rhinitis

  • Cold

  • Coryza

  • Head Cold

  • Infective Nasopharyngitis

  • Rhinopharyngitis

  • Acute Nasal Catarrh

  • Infective Rhinitis

  • Acute Nasopharyngeal Catarrh

  • Infective Nasopharyngitis Nos

  • Nasopharyngitis Nos

  • Epipharyngitis

  • Mucositis Nos

  • Inflammatory Disease Of Mucous Membrane

  • Mucosal Inflammation
Fruit Allergy

  • Allergy To Fruit
Conjunctivitis

  • Madras Eye

  • Adenoviral Conjunctivitis

  • Acute Adenoviral Follicular Conjunctivitis

  • Inclusion Conjunctivitis Of The Adult

  • Swimming-Pool Conjunctivitis

  • Inflammation Of Conjunctiva

  • Ophthalmia

  • Acute Conjunctivitis

  • Eye Catarrh

  • Catarrhal Ophthalmia

  • Koch-Weeks Conjunctivitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15950 AZD1981 Antagonist 99.80% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11370 PTGDR Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11371 PTGDR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11372 Ptgdr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11373 Ptgdr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PTGDR2 VGNC VGNC:33500
Macaca mulatta PTGDR2 VGNC VGNC:76358
Rattus norvegicus PTGDR2 RGD RGD:1311986
Felis catus PTGDR2 VGNC VGNC:104317
Canis familiaris PTGDR2 VGNC VGNC:45141
Mus musculus PTGDR2 MGD MGI:1330275
Others PTGDR2 NCBI