SLCO2B1 - solute carrier organic anion transporter family member 2B1 Gene

Also Known as OATPB; OATP-B; OATP2B1; SLC21A9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11309

About SLCO2B1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:75,151,107-75,206,549 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 10 paralogues. Broad expression in liver (RPKM 44.0), lung (RPKM 34.3) and 23 other tissues.

Summary

This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated Steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

SLCO2B1 Products (3)

mRNA Protein Name
NM_001145211.3 NP_001138683.1 solute carrier organic anion transporter family member 2B1 isoform 2
NM_001145212.3 NP_001138684.1 solute carrier organic anion transporter family member 2B1 isoform 3
NM_007256.5 NP_009187.1 solute carrier organic anion transporter family member 2B1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
10873595 GOA
enables organic anion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
29871943 GOA
enables prostaglandin transmembrane transporter activity IDA
IDA: Inferred from direct assay
10873595 GOA
enables sodium-independent organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
18501590 GOA
enables transmembrane transporter activity IDA
IDA: Inferred from direct assay
25132355 GOA
Biological Process GO Annotation Evidence References Source
involved in organic anion transport IDA
IDA: Inferred from direct assay
12724351 GOA
involved in transmembrane transport IDA
IDA: Inferred from direct assay
12724351 GOA
involved in transmembrane transport IMP
IMP: Inferred from mutant phenotype
29752999 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12724351 GOA
located in basal plasma membrane IDA
IDA: Inferred from direct assay
11159893 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
21278488 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLCO2B1 Protein Structure

OATP

OATP: Organic Anion Transporter Polypeptide (OATP) family (48 - 648)

  • 0
  • 200
  • 400
  • 600
  • 709 a.a.
Protein Preferred Names Protein Names

solute carrier organic anion transporter family member 2B1

  • OATP-RP2

Related Diseases

Diseases Alias
Bronchiectasis 3
Ileum Cancer

  • Ileal Neoplasm

  • Malignant Neoplasm Of Ileum

  • Ileal Cancer

  • Ileal Neoplasms
Myasthenic Syndrome, Congenital, 1b, Fast-Channel

  • CMS1B

  • Congenital Myasthenic Syndrome 1b

  • Myasthenic Syndrome, Congenital, Fast-Channel

  • Congenital Myasthenic Syndrome 1b, Fast-Channel

  • Fccms

  • Myasthenic Syndrome, Fast-Channel Congenital

  • Myasthenic Syndrome, Congenital, Type 1b, Fast-Channel

  • Congenital Myasthenic Syndrome Ib
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13356 SLCO2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLCO2B1 RGD RGD:621391
Macaca mulatta SLCO2B1 VGNC VGNC:77603
Mus musculus SLCO2B1 MGD MGI:1351872
Bos taurus SLCO2B1 VGNC VGNC:34952
Canis familiaris SLCO2B1 VGNC VGNC:46496
Felis catus SLCO2B1 VGNC VGNC:65445
Others SLCO2B1 NCBI