Acadm - acyl-Coenzyme A dehydrogenase, medium chain Gene

Also Known as MCAD

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11364

Summary

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]

Acadm Products (1)

mRNA Protein Name
NM_007382.5 NP_031408.1 medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables medium-chain fatty acyl-CoA dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
18459129 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
16121256 MGI
acts upstream of or within carnitine metabolic process IMP
IMP: Inferred from mutant phenotype
16121256 MGI
involved in carnitine metabolic process, CoA-linked IMP
IMP: Inferred from mutant phenotype
18459129 MGI
involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase IMP
IMP: Inferred from mutant phenotype
18459129 MGI
involved in glycogen biosynthetic process IMP
IMP: Inferred from mutant phenotype
18459129 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
16121256 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
16121256 MGI
involved in medium-chain fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
18459129 MGI
acts upstream of or within organic acid metabolic process IMP
IMP: Inferred from mutant phenotype
16121256 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
16121256 MGI
involved in regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
18459129 MGI
acts upstream of or within response to cold IMP
IMP: Inferred from mutant phenotype
16121256 MGI
acts upstream of or within response to starvation IMP
IMP: Inferred from mutant phenotype
16121256 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
26767982 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00128 ACADM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17544 Acadm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24002 Acadm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acadm NCBI NCBI:34