Macf1 - microtubule-actin crosslinking factor 1 Gene

Also Known as Acf7; MACF; Aclp7; ABP620; mKIAA0465; mKIAA0754; D830031N03Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11426

Summary

Enables actin binding activity and microtubule binding activity. Involved in several processes, including positive regulation of Wnt signaling pathway; regulation of focal adhesion assembly; and regulation of neuron projection arborization. Acts upstream of or within several processes, including Wnt signaling pathway; mesoderm formation; and posttranslational protein targeting to endoplasmic reticulum membrane. Located in cytoplasm; cytoskeleton; and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; limb segment; lung; and skeletal musculature. Human ortholog(s) of this gene implicated in lissencephaly 9 with complex brainstem malformation. Orthologous to human MACF1 (microtubule actin crosslinking factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Macf1 Products (4)

mRNA	Protein	Name
NM_001199136.2	NP_001186065.1	microtubule-actin cross-linking factor 1 isoform 1
NM_001199137.2	NP_001186066.1	microtubule-actin cross-linking factor 1 isoform 2
NM_001401293.2	NP_001388222.1	microtubule-actin cross-linking factor 1 isoform 3
NM_001401294.2	NP_001388223.1	microtubule-actin cross-linking factor 1 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	18854161	MGI
enables actin binding	IDA IDA: Inferred from direct assay	14636561	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	14636561	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16815997	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16815997	MGI
acts upstream of or within Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16815997	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	14636561	MGI
acts upstream of or within establishment or maintenance of cell polarity	IMP IMP: Inferred from mutant phenotype	14636561	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	16815997	MGI
involved in positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16815997	MGI
acts upstream of or within post-translational protein targeting to endoplasmic reticulum membrane	IMP IMP: Inferred from mutant phenotype	16815997	MGI
involved in regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	18854161	MGI
involved in regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	18854161	MGI
involved in regulation of microtubule-based process	IMP IMP: Inferred from mutant phenotype	21295697	MGI
involved in regulation of neuron projection arborization	IMP IMP: Inferred from mutant phenotype	26526844	MGI
involved in wound healing	IMP IMP: Inferred from mutant phenotype	18854161	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	14636561	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	21295697	MGI
located in microtubule	IDA IDA: Inferred from direct assay	18854161	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	14636561	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
microtubule-actin cross-linking factor 1	actin cross-linking family 7 actin-crosslinking protein 7 trabeculin alpha

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07942	MACF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22621	Macf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29136	Macf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Macf1	NCBI	NCBI:23499