Chrna7 - cholinergic receptor, nicotinic, alpha polypeptide 7 Gene

Also Known as Acra7; nAchR; alpha7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11441

Summary

Enables acetylcholine-gated cation-selective channel activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell communication; and regulation of protein metabolic process. Acts upstream of or within several processes, including behavioral response to ethanol; learning or memory; and negative regulation of cytokine production. Located in apical plasma membrane; axolemma; and external side of plasma membrane. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Is active in cholinergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion). [provided by Alliance of Genome Resources, Apr 2022]

Chrna7 Products (1)

mRNA Protein Name
NM_007390.3 NP_031416.3 neuronal acetylcholine receptor subunit alpha-7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: Inferred from direct assay
9495872 MGI
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: Inferred from mutant phenotype
9037516 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11906696 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell activation IMP
IMP: Inferred from mutant phenotype
15963492 MGI
acts upstream of or within T cell activation IMP
IMP: Inferred from mutant phenotype
16253349 MGI
acts upstream of or within associative learning IGI
IGI: Inferred from genetic interaction
15541879 MGI
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
15922075 MGI
acts upstream of or within behavioral response to ethanol IMP
IMP: Inferred from mutant phenotype
15489024 MGI
acts upstream of or within behavioral response to nicotine IGI
IGI: Inferred from genetic interaction
17470777 MGI
involved in dendrite arborization IMP
IMP: Inferred from mutant phenotype
23270857 MGI
involved in dendritic spine organization IMP
IMP: Inferred from mutant phenotype
23270857 MGI
acts upstream of or within endocytosis IMP
IMP: Inferred from mutant phenotype
16025111 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
9364063 MGI
acts upstream of or within flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
15944242 MGI
acts upstream of or within generation of ovulation cycle rhythm IMP
IMP: Inferred from mutant phenotype
15364017 MGI
acts upstream of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
12508119 MGI
acts upstream of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
12508119 MGI
involved in learning or memory IGI
IGI: Inferred from genetic interaction
19118188 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
16923147 MGI
involved in modulation of chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
20943921 MGI
involved in modulation of excitatory postsynaptic potential IDA
IDA: Inferred from direct assay
20974225 MGI
involved in modulation of excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
20974225 MGI
acts upstream of or within monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
9364063 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
16785311 MGI
acts upstream of or within negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
12508119 MGI
acts upstream of or within negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
12508119 MGI
involved in negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
19230830 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
12508119 MGI
acts upstream of or within ovulation cycle IMP
IMP: Inferred from mutant phenotype
1400473 MGI
involved in positive regulation of CoA-transferase activity IGI
IGI: Inferred from genetic interaction
20164328 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17898229 MGI
involved in positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
20164328 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
11404397 MGI
involved in positive regulation of amyloid-beta formation IGI
IGI: Inferred from genetic interaction
20164328 MGI
involved in positive regulation of excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
19118188 MGI
acts upstream of or within positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
10942027 MGI
involved in positive regulation of long-term synaptic potentiation IDA
IDA: Inferred from direct assay
20974225 MGI
involved in positive regulation of long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
19118188 MGI
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
19230830 MGI
involved in positive regulation of protein metabolic process IGI
IGI: Inferred from genetic interaction
20164328 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
17898229 MGI
involved in regulation of amyloid fibril formation IGI
IGI: Inferred from genetic interaction
20164328 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
12508119 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
9364063 MGI
acts upstream of or within regulation of norepinephrine secretion IMP
IMP: Inferred from mutant phenotype
10942027 MGI
involved in regulation of synapse structural plasticity IMP
IMP: Inferred from mutant phenotype
20164328 MGI
acts upstream of or within regulation of synaptic transmission, dopaminergic IMP
IMP: Inferred from mutant phenotype
16772172 MGI
involved in response to amyloid-beta IMP
IMP: Inferred from mutant phenotype
19118188 MGI
involved in response to cold IDA
IDA: Inferred from direct assay
19230830 MGI
acts upstream of or within response to ethanol IMP
IMP: Inferred from mutant phenotype
15555774 MGI
acts upstream of or within response to food IMP
IMP: Inferred from mutant phenotype
15922075 MGI
involved in response to nicotine IGI
IGI: Inferred from genetic interaction
11404397 MGI
acts upstream of or within response to nicotine IMP
IMP: Inferred from mutant phenotype
9495872 MGI
involved in sensory processing IDA
IDA: Inferred from direct assay
17898229 MGI
involved in synapse organization IGI
IGI: Inferred from genetic interaction
19587288 MGI
involved in synaptic transmission, cholinergic IGI
IGI: Inferred from genetic interaction
20164328 MGI
acts upstream of or within synaptic transmission, cholinergic IMP
IMP: Inferred from mutant phenotype
9364063 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
12508119 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16033766 MGI
located in axolemma IDA
IDA: Inferred from direct assay
18458158 MGI
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
12079404 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15963492 MGI
located in membrane IDA
IDA: Inferred from direct assay
11834293 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
24607281 MGI
is active in postsynaptic membrane IEP
IEP: Inferred from expression pattern
24607281 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
12079404 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
24607281 MGI
is active in presynaptic membrane IEP
IEP: Inferred from expression pattern
24607281 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-7

  • acetylcholine receptor alpha 7 neural

  • alpha7 nicotinic receptor

  • alpha7-nAChR

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02672 CHRNA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02659 CHRFAM7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19768 Chrna7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26265 Chrna7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrna7 NCBI NCBI:1139