CARD16 - caspase recruitment domain family member 16 Gene

Also Known as COP; COP1; PSEUDO-ICE; LLID-114769

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114769

About CARD16

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:105,041,563-105,045,335 (from NCBI)

This gene has 5 transcripts (splice variants), 424 orthologues and 16 paralogues. Broad expression in spleen (RPKM 14.0), appendix (RPKM 12.0) and 23 other tissues.

Summary

Enables several functions, including CARD domain binding activity; cysteine-type endopeptidase inhibitor activity; and enzyme binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of signal transduction. Part of protease inhibitor complex. [provided by Alliance of Genome Resources, Apr 2022]

CARD16 Products (2)

mRNA	Protein	Name
NM_001394580.1	NP_001381509.1	caspase recruitment domain-containing protein 16 isoform 3
NM_052889.4	NP_443121.1	caspase recruitment domain-containing protein 16 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	11821383	GOA
enables caspase binding	IPI IPI: Inferred from physical interaction	11432859	GOA
enables cysteine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	16920334	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	11432859	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	11432859	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11536016	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	15383541	GOA
involved in inhibition of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	11432859	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16920334	GOA
involved in negative regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	11432859	GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	11432859	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	11432859	GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16920334	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	11536016	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15383541	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protease inhibitor complex	IDA IDA: Inferred from direct assay	11432859	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11536016	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD16 Protein Structure

CARD

0
100
197 a.a.

Protein Preferred Names	Protein Names
caspase recruitment domain-containing protein 16	CARD only domain-containing protein 1

Related Diseases

Diseases	Alias
Vestibulocochlear Nerve Disease	Vestibulocochlear Nerve Diseases Acoustic Nerve Disease Cochlear Nerve Diseases Disturbance Of Vestibulocochlear Nerve Auditory Nerve Disorder Disorder Of Acoustovestibular Nerve Disorder Of Eighth Nerve Eighth Cranial Nerve Disorder Disease Of Eighth Cranial Nerve Disease Of Acoustic Nerve Disease Of Auditory Nerve Disorder Of 8th Cranial Nerve Auditory Nerve Lesion Cochlear Nerve Disorder
Vestibular Neuronitis	Vestibular Neuritis Epidemic Neurolabyrinthitis
Colon Sarcoma	Colonic Sarcoma
Ehlers-Danlos Syndrome, Hypermobility Type	Ehlers-Danlos Syndrome, Type 3 Ehlers-Danlos Syndrome, Type Iii EDSHMB Eds Iii Benign Hypermobility Syndrome Ehlers-Danlos Syndrome Hypermobility Type Eds3 Type Iii Ehlers-Danlos Syndrome Ehlers-Danlos Syndrome Type 3 Es-D3
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01918	CARD16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown