Dusp1 - dual specificity phosphatase 1 Gene

Also Known as Mkp1; CL100; MKP-1; 3CH134; Ptpn16

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114856

Summary

This gene encodes a protein that catalyzes the dephosphorylation and inactivation of MAP kinase, and may be involved in Insulin mediated signalling. [provided by RefSeq, Jul 2008]

Dusp1 Products (1)

mRNA Protein Name
NM_053769.4 NP_446221.2 dual specificity protein phosphatase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables growth factor binding IPI
IPI: Inferred from physical interaction
18929742 RGD
enables protein tyrosine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
12435803 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
15358679 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
11423551 RGD
involved in negative regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
10446064 RGD
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17437549 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15059639 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
9228085 RGD
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
12435803 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
15358679 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
11423551 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
8804359 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
17403137 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
7540516 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
15527789 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
15494319 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
8804359 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 1

  • 3CH134/CL100 PTPase

  • MAP kinase phosphatase-1

  • mitogen-activated protein (MAP) kinase phosphatase-1

  • mitogen-activated protein kinase phosphatase 1

  • oxidative stress-inducible protein tyrosine phosphatase

  • protein-tyrosine phosphatase CL100

  • protein-tyros

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2179 Hypaphorine Inhibitor 99.93% Unkown
HY-RS04050 DUSP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04053 DUSP12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16828 Dusp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23270 Dusp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp1 NCBI NCBI:1843