SLC26A9 - solute carrier family 26 member 9 Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 115019

About SLC26A9

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,913,052-205,943,456 (from NCBI)

This gene has 6 transcripts (splice variants), 187 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in salivary gland (RPKM 19.0), stomach (RPKM 12.3) and 5 other tissues.

Summary

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK Kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]

SLC26A9 Products (2)

mRNA	Protein	Name
NM_052934.4	NP_443166.1	solute carrier family 26 member 9 isoform a
NM_134325.3	NP_599152.2	solute carrier family 26 member 9 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables ATPase binding	IPI IPI: Inferred from physical interaction	19289574	GOA
enables chloride channel activity	IDA IDA: Inferred from direct assay	17673510	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28360110	GOA
enables solute:inorganic anion antiporter activity	IDA IDA: Inferred from direct assay	15800055	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	15800055	GOA
involved in chloride transport	IDA IDA: Inferred from direct assay	17673510	GOA
involved in monoatomic anion transport	IDA IDA: Inferred from direct assay	17673510	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	20658517	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
is active in Golgi membrane	IDA IDA: Inferred from direct assay	26801567	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	20658517	GOA
located in cell surface	IDA IDA: Inferred from direct assay	17673510	GOA
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	26801567	GOA
is active in endosome membrane	IDA IDA: Inferred from direct assay	26801567	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	26801567	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC26A9 Protein Structure

Sulfate_transp

STAS

0
200
400
600
791 a.a.

Protein Preferred Names	Protein Names
solute carrier family 26 member 9	anion transporter/exchanger protein 9

関連疾患

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Ileus	Ileus Of Intestine
Parotid Gland Cancer	Cancer Of Parotid Gland Parotid Neoplasms Malignant Neoplasm Of The Parotid Malignant Tumor Of Parotid Gland Parotid Cancer Parotid Neoplasm Parotid Gland Carcinoma Cancer Of Parotid Malignant Tumour Of Parotid Gland Parotid Duct Cancer Parotid Ductal Cancer Parotid Glandular Cancer Primary Malignant Neoplasm Of Parotid Gland
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-159706	S9-A13	Inhibitor	/	Unkown
HY-RS13143	SLC26A9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	SLC26A9	MGD	MGI:2444594
Bos taurus	SLC26A9	VGNC	VGNC:34784
Macaca mulatta	SLC26A9	VGNC	VGNC:77480
Felis catus	SLC26A9	VGNC	VGNC:65287
Canis familiaris	SLC26A9	VGNC	VGNC:46328
Rattus norvegicus	SLC26A9	RGD	RGD:1310441
Others	SLC26A9	NCBI