ALPK2 - alpha kinase 2 Gene

Also Known as HAK

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115701

About ALPK2

Cytogenetic location: 18q21.31-q21.32 Genomic coordinates (GRCh38): 18:58,481,247-58,629,091 (from NCBI)

This gene has 6 transcripts (splice variants), 171 orthologues and 4 paralogues. Biased expression in heart (RPKM 9.8), lymph node (RPKM 2.0) and 4 other tissues.

Summary

Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in several processes, including epicardium morphogenesis; heart development; and negative regulation of Wnt signaling pathway involved in heart development. Acts upstream of or within regulation of gene expression. Colocalizes with basolateral plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ALPK2 Products (1)

mRNA Protein Name
NM_052947.4 NP_443179.3 alpha-protein kinase 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
29888752 GOA
involved in epicardium morphogenesis IMP
IMP: Inferred from mutant phenotype
29888752 GOA
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
28668886 GOA
involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
29888752 GOA
involved in negative regulation of Wnt signaling pathway involved in heart development IMP
IMP: Inferred from mutant phenotype
29888752 GOA
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22641666 GOA
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22641666 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with basolateral plasma membrane IMP
IMP: Inferred from mutant phenotype
28668886 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALPK2 Protein Structure

I-set

I-set: Immunoglobulin I-set domain (15 - 104)

I-set

I-set: Immunoglobulin I-set domain (1803 - 1874)

Alpha_kinase

Alpha_kinase: Alpha-kinase family (1925 - 2125)

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  • 2000
  • 2170 a.a.
Protein Preferred Names Protein Names

alpha-protein kinase 2

  • heart alpha-kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00630 ALPK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22388 Alpk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28912 Alpk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ALPK2 VGNC VGNC:59760
Mus musculus ALPK2 MGD MGI:2449492
Rattus norvegicus ALPK2 RGD RGD:1564431
Bos taurus ALPK2 VGNC VGNC:25848
Canis familiaris ALPK2 VGNC VGNC:37816
Macaca mulatta ALPK2 VGNC VGNC:69648
Others ALPK2 NCBI