Lmnb1 - lamin B1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116685

Summary

Predicted to enable Phospholipase binding activity and sequence-specific double-stranded DNA binding activity. Involved in several processes, including cellular response to corticosterone stimulus; cellular response to monosodium L-glutamate; and response to Antibiotic. Located in cytoplasm; nuclear membrane; and nuclear periphery. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Apr 2022]

Lmnb1 Products (1)

mRNA Protein Name
NM_053905.2 NP_446357.2 lamin-B1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21277044 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to L-glutamate IDA
IDA: Inferred from direct assay
21389115 RGD
involved in cellular response to corticosterone stimulus IEP
IEP: Inferred from expression pattern
15755911 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16548065 RGD
involved in neurogenesis IEP
IEP: Inferred from expression pattern
17432957 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
24780913 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
20204270 RGD
located in nuclear lamina IDA
IDA: Inferred from direct assay
16950509 RGD
located in nuclear matrix IDA
IDA: Inferred from direct assay
12243746 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
16575512 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lamin-B1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07715 LMNB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19706 Lmnb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26202 Lmnb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lmnb1 NCBI NCBI:4001