Slc25a4 - solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Gene

Also Known as Ant1; mANC1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11739

Summary

Enables ATP:ADP antiporter activity; Oxidative Phosphorylation uncoupler activity; and proton transmembrane transporter activity. Involved in several processes, including adenine nucleotide transport; positive regulation of mitophagy; and regulation of mitochondrial membrane permeability. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial inner membrane and myelin sheath. Part of mitochondrial permeability transition pore complex. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc25a4 Products (1)

mRNA Protein Name
NM_007450.5 NP_031476.3 ADP/ATP translocase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP:ADP antiporter activity IDA
IDA: Inferred from direct assay
31341297 MGI
enables ATP:ADP antiporter activity IMP
IMP: Inferred from mutant phenotype
31618756 MGI
enables oxidative phosphorylation uncoupler activity IDA
IDA: Inferred from direct assay
31341297 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11809823 MGI
enables proton transmembrane transporter activity IDA
IDA: Inferred from direct assay
31341297 MGI
Biological Process GO Annotation Evidence References Source
involved in adaptive thermogenesis IMP
IMP: Inferred from mutant phenotype
31341297 MGI
acts upstream of or within apoptotic mitochondrial changes IGI
IGI: Inferred from genetic interaction
18350175 MGI
involved in mitochondrial ADP transmembrane transport IDA
IDA: Inferred from direct assay
31341297 MGI
involved in mitochondrial ADP transmembrane transport IMP
IMP: Inferred from mutant phenotype
31618756 MGI
involved in mitochondrial ATP transmembrane transport IDA
IDA: Inferred from direct assay
31341297 MGI
involved in mitochondrial ATP transmembrane transport IMP
IMP: Inferred from mutant phenotype
31618756 MGI
involved in positive regulation of mitophagy IDA
IDA: Inferred from direct assay
31618756 MGI
involved in regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
31489369 MGI
Cellular Component GO Annotation Evidence References Source
part of mitochondrial permeability transition pore complex IMP
IMP: Inferred from mutant phenotype
31489369 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADP/ATP translocase 1

  • ADP,ATP carrier protein 1

  • ADP,ATP carrier protein, heart/skeletal muscle

  • ANT 1

  • adenine nucleotide translocase-1

  • adenine nucleotide translocator 1, skeletal muscle

  • solute carrier family 25 member 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22037 Slc25a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13122 SLC25A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28554 Slc25a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc25a4 NCBI NCBI:291