Anxa7 - annexin A7 Gene

Also Known as Anx7; synexin

Species: Mus musculus

Gene Type: protein coding

Gene ID: 11750

Summary

Predicted to enable several functions, including calcium-dependent phospholipid binding activity; calcium-dependent protein binding activity; and Integrin binding activity. Acts upstream of or within several processes, including cellular chemical homeostasis; hemostasis; and response to salt stress. Located in several cellular components, including cytosol; nuclear envelope; and vesicle. Orthologous to human ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Apr 2022]

Anxa7 Products (3)

mRNA	Protein	Name
NM_001110794.1	NP_001104264.1	annexin A7
NM_001374757.1	NP_001361686.1	annexin A7 isoform 3
NM_009674.3	NP_033804.2	annexin A7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase-dependent fusogenic activity	IMP IMP: Inferred from mutant phenotype	10570150	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14644162	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of establishment of localization in cell	IGI IGI: Inferred from genetic interaction	20440069	MGI
acts upstream of or within glial cell proliferation	IMP IMP: Inferred from mutant phenotype	14644162	MGI
acts upstream of or within hemostasis	IMP IMP: Inferred from mutant phenotype	12925238	MGI
acts upstream of insulin secretion	IGI IGI: Inferred from genetic interaction	20440069	MGI
acts upstream of or within intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	14644162	MGI
acts upstream of or within intracellular water homeostasis	IMP IMP: Inferred from mutant phenotype	12925238	MGI
acts upstream of or within positive effect ion channel modulating, G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10570150	MGI
acts upstream of or within positive effect ligand-gated ion channel signaling pathway	IMP IMP: Inferred from mutant phenotype	10570150	MGI
acts upstream of or within positive effect phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	10570150	MGI
acts upstream of or within positive effect positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	10570150	MGI
acts upstream of or within regulation of cell shape	IMP IMP: Inferred from mutant phenotype	12925238	MGI
acts upstream of or within response to salt stress	IMP IMP: Inferred from mutant phenotype	12925238	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	15819996	MGI
located in nuclear envelope	IDA IDA: Inferred from direct assay	14644162	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15819996	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14644162	MGI
located in vesicle	IDA IDA: Inferred from direct assay	12925238	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
annexin A7	annexin VII annexin-7

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115635	ABO hydrochloride	Modulator	98.70%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Anxa7	NCBI	NCBI:310