CLCA1 - chloride channel accessory 1 Gene

Also Known as CACC; GOB5; CACC1; CLCRG1; CaCC-1; hCLCA1; hCaCC-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1179

About CLCA1

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:86,468,927-86,500,259 (from NCBI)

This gene has 2 transcripts (splice variants), 237 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 634.9), duodenum (RPKM 392.5) and 2 other tissues.

Summary

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]

CLCA1 Products (1)

mRNA Protein Name
NM_001285.4 NP_001276.3 calcium-activated chloride channel regulator 1 precursor

CLCA1 Protein Structure

CLCA

CLCA: Calcium-activated chloride channel N terminal (1 - 262)

VWA_2

VWA_2: von Willebrand factor type A domain (307 - 463)

(486 - 660)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 914 a.a.
Protein Preferred Names Protein Names

calcium-activated chloride channel regulator 1

  • CLCA family member 1, chloride channel regulator

Related Diseases

Diseases Alias
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Pontocerebellar Hypoplasia, Type 9

  • Pontocerebellar Hypoplasia Type 9

  • PCH9

  • Pontocerebellar Hypoplasia 9

  • Hypoplasia, Pontocerebellar, Type 9
Ileus

  • Ileus Of Intestine
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
T2-High Asthma

  • Type 2 High Endotype
Pulmonary Disease, Chronic Obstructive

  • Chronic Obstructive Pulmonary Disease

  • COPD

  • Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

  • Chronic Obstructive Lung Disease

  • Chronic Obstructive Airway Disease

  • Pulmonary Disease, Chronic Obstructive, Susceptibility To

  • Cold

  • Severe Early-Onset Chronic Obstructive Pulmonary Disease

  • Pulmonary Disease Chronic Obstructive

  • Pulmonary Disease, Obstructive, Chronic, Susceptibility To

  • Chronic Obstructive Pulmonary Disease Of Horses

  • Common Cold

  • Upper Respiratory Infections

  • Copd - [Chronic Obstructive Pulmonary Disease]

  • Coad - [Chronic Obstructive Airways Disease]

  • Cold - [Chronic Obstructive Lung Disease]

  • Chronic Airway Disease Nos

  • Chronic Airways Limitation, Unspecified

  • Chronic Obstructed Airway, Unspecified

  • Chronic Obstructive Airway Disease, Unspecified

  • Chronic Obstructive Airway, Unspecified

  • Obstructive Lung Disease Nos

  • Chronic Obstructive Lung Disease Nos

  • Chronic Obstructive Lung Nos

  • Obstructive Pulmonary Disease Nos

  • Exacerbation Copd Nos

  • Acute Exacerbation Copd
Adult-Onset Severe Asthma
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02748 CLCA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLCA1 VGNC VGNC:27392
Canis familiaris CLCA1 VGNC VGNC:39296
Rattus norvegicus CLCA1 RGD RGD:1306258
Felis catus CLCA1 VGNC VGNC:60918
Mus musculus CLCA1 MGD MGI:1346342
Others CLCA1 NCBI