Apex1 - apurinic/apyrimidinic endonuclease 1 Gene

Also Known as APE; Apex; HAP1; Ref-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11792

Summary

Predicted to enable several functions, including DNA binding activity; NF-kappaB binding activity; and nuclease activity. Acts upstream of or within cell redox homeostasis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; autopod; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ Cancer (multiple); spina bifida; and urinary bladder Cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]

Apex1 Products (1)

mRNA Protein Name
NM_009687.2 NP_033817.1 DNA-(apurinic or apyrimidinic site) endonuclease

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell redox homeostasis IDA
IDA: Inferred from direct assay
14594818 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14594818 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14594818 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-(apurinic or apyrimidinic site) endonuclease

  • AP endonuclease 1

  • APEN

  • APEX nuclease

  • DNA-(apurinic or apyrimidinic site) lyase

  • redox factor-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00815 APEX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21480 Apex1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27998 Apex1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apex1 NCBI NCBI:328