Bmpr1b - bone morphogenetic protein receptor, type 1B Gene

Also Known as Alk6; SKR6; ALK-6; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12167

About Bmpr1b

Chromosome 3: 141,542,897-141,875,186 reverse strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 290 orthologues, 11 paralogues and is associated with 39 phenotypes. Biased expression in limb E14.5 (RPKM 1.8), frontal lobe adult (RPKM 1.8) and 11 other tissues.

Summary

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Bmpr1b Products (6)

mRNA Protein Name
NM_001277217.3 NP_001264146.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277220.2 NP_001264149.1 bone morphogenetic protein receptor type-1B isoform b
NM_007560.5 NP_031586.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277216.3 NP_001264145.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001355043.2 NP_001341972.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277218.2 NP_001264147.1 bone morphogenetic protein receptor type-1B isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BMP binding IDA
IDA: Inferred from direct assay
11714695 MGI
enables BMP receptor activity IDA
IDA: Inferred from direct assay
11714695 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15239668 MGI
enables transforming growth factor beta receptor activity, type I IMP
IMP: Inferred from mutant phenotype
11376112 MGI
enables transmembrane receptor protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
14523231 MGI
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IDA
IDA: Inferred from direct assay
11714695 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
16049014 MGI
acts upstream of or within BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
11376112 MGI
involved in bone development IMP
IMP: Inferred from mutant phenotype
20551513 MGI
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
15673568 MGI
acts upstream of or within cartilage condensation IMP
IMP: Inferred from mutant phenotype
10631181 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
12117821 MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway IGI
IGI: Inferred from genetic interaction
18363966 MGI
involved in cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
24129431 MGI
acts upstream of or within central nervous system neuron differentiation IGI
IGI: Inferred from genetic interaction
15469980 MGI
acts upstream of or within chondrocyte differentiation IGI
IGI: Inferred from genetic interaction
18363966 MGI
involved in chondrocyte differentiation IMP
IMP: Inferred from mutant phenotype
24098149 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
15673568 MGI
acts upstream of or within eye development IMP
IMP: Inferred from mutant phenotype
12117821 MGI
involved in inflammatory response IEP
IEP: Inferred from expression pattern
12151307 MGI
involved in osteoblast differentiation IDA
IDA: Inferred from direct assay
20551513 MGI
involved in ovarian cumulus expansion IMP
IMP: Inferred from mutant phenotype
11416163 MGI
involved in ovulation cycle IMP
IMP: Inferred from mutant phenotype
11416163 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
IGI: Inferred from genetic interaction
18363966 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
12654290 MGI
acts upstream of or within retinal ganglion cell axon guidance IMP
IMP: Inferred from mutant phenotype
12654290 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
24129431 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bmpr1b Protein Structure

Activin_recp

Activin_recp: pfam01064 (29 - 105)

STKc_BMPR1b

STKc_BMPR1b: cd14219 (197 - 501)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein receptor type-1B

  • BMP type-1B receptor

  • activin receptor-like kinase 6

  • serine/threonine-protein kinase receptor R6

Recombinant Bmpr1b Proteins

Cat. No. Product Name Accession Purity
HY-P76176 BMPRIB/ALK-6 Protein, Mouse (HEK293, Fc) P36898 (K14-K126) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01549 BMPR1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01550 Bmpr1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01551 Bmpr1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174774 Human BMPR1B mRNA / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991882 Anti-BMPR1B Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmpr1b NCBI NCBI:658