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  3. Bmpr1b - bone morphogenetic protein receptor, type 1B Gene

Bmpr1b - bone morphogenetic protein receptor, type 1B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Alk6; SKR6; ALK-6; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a

Gene ID: 12167 | Gene type: protein coding

About Bmpr1b

Chromosome 3: 141,542,897-141,875,186 reverse strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 290 orthologues, 11 paralogues and is associated with 39 phenotypes. Biased expression in limb E14.5 (RPKM 1.8), frontal lobe adult (RPKM 1.8) and 11 other tissues.

Summary

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Bmpr1b Products(6)

mRNA Protein Name
NM_001277217.3 NP_001264146.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277220.2 NP_001264149.1 bone morphogenetic protein receptor type-1B isoform b
NM_007560.5 NP_031586.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277216.3 NP_001264145.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001355043.2 NP_001341972.1 bone morphogenetic protein receptor type-1B isoform a precursor
NM_001277218.2 NP_001264147.1 bone morphogenetic protein receptor type-1B isoform a precursor

Bmpr1b Protein Structure

Activin_recp

Activin_recp: pfam01064 (29 - 105)

STKc_BMPR1b

STKc_BMPR1b: cd14219 (197 - 501)

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  • 502 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein receptor type-1B

BMP type-1B receptor

activin receptor-like kinase 6

serine/threonine-protein kinase receptor R6

Recombinant Bmpr1b Proteins

Cat. No. Product Name Accession Purity
HY-P76176 BMPRIB/ALK-6 Protein, Mouse (HEK293, Fc) P36898 (K14-K126) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01549 BMPR1B Human Pre-designed siRNA Set A / Unkown
HY-RS01550 Bmpr1b Mouse Pre-designed siRNA Set A / Unkown
HY-RS01551 Bmpr1b Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmpr1b NCBI NCBI:658