Cacna1s - calcium channel, voltage-dependent, L type, alpha 1S subunit Gene

Also Known as sj; fmd; mdg; DHPR; Cav1.1; Cchl1a3; DHPR alpha1s

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12292

Summary

Enables voltage-gated Calcium Channel activity. Acts upstream of or within several processes, including extraocular skeletal muscle development; myotube differentiation; and skeletal muscle adaptation. Located in T-tubule and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skeletal musculature. Used to study hypokalemic periodic paralysis. Human ortholog(s) of this gene implicated in hypokalemic periodic paralysis and malignant hyperthermia. Orthologous to human CACNA1S (calcium voltage-gated channel subunit alpha1 S). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1s Products (3)

mRNA Protein Name
NM_001081023.3 NP_001074492.1 voltage-dependent L-type calcium channel subunit alpha-1S isoform 2
NM_001402949.1 NP_001389878.1 voltage-dependent L-type calcium channel subunit alpha-1S isoform 3
NM_014193.4 NP_055008.2 voltage-dependent L-type calcium channel subunit alpha-1S isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
12954602 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
9929471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
12954602 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
1663002 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
5041196 MGI
acts upstream of or within extraocular skeletal muscle development IMP
IMP: Inferred from mutant phenotype
14618389 MGI
acts upstream of or within muscle cell development IMP
IMP: Inferred from mutant phenotype
5041196 MGI
acts upstream of or within muscle contraction IDA
IDA: Inferred from direct assay
8143864 MGI
acts upstream of or within muscle contraction IMP
IMP: Inferred from mutant phenotype
4738109 MGI
acts upstream of or within myoblast fusion IMP
IMP: Inferred from mutant phenotype
10949052 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
6692971 MGI
acts upstream of or within skeletal muscle adaptation IMP
IMP: Inferred from mutant phenotype
2419767 MGI
acts upstream of or within skeletal muscle fiber development IDA
IDA: Inferred from direct assay
8143864 MGI
acts upstream of or within skeletal muscle fiber development IMP
IMP: Inferred from mutant phenotype
289331 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
6500174 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
6501560 MGI
acts upstream of or within striated muscle contraction IMP
IMP: Inferred from mutant phenotype
1281468 MGI
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
8943043 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
8943043 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit alpha-1S

  • dihydropyridine receptor alpha 1S

  • muscle dysgenesis

  • voltage-gated calcium channel subunit alpha Cav1.1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01800 CACNA1S Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21234 Cacna1s Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27751 Cacna1s Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1s NCBI NCBI:779