2. Gene
  3. ACOT4 - acyl-CoA thioesterase 4 Gene

ACOT4 - acyl-CoA thioesterase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PTE1B; PTE2B; PTE-Ib

Gene ID: 122970 | Gene type: protein coding

About ACOT4

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,591,873-73,595,766 (from NCBI)

This gene has 1 transcript (splice variant), 389 orthologues and 4 paralogues. Broad expression in kidney (RPKM 4.8), liver (RPKM 2.8) and 21 other tissues.

Summary

Enables acyl-CoA hydrolase activity and succinyl-CoA hydrolase activity. Involved in carboxylic acid metabolic process; saturated monocarboxylic acid metabolic process; and succinyl-CoA metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

ACOT4 Products(1)

mRNA Protein Name
NM_152331.4 NP_689544.3 peroxisomal succinyl-coenzyme A thioesterase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
16141203 GOA
enables succinyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
16141203 GOA
Biological Process GO Annotation Evidence Reference Source
involved in acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
NOT involved in butyrate metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in dicarboxylic acid catabolic process IDA
IDA: Inferred from direct assay
16141203 GOA
involved in dicarboxylic acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in saturated monocarboxylic acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in short-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in succinyl-CoA metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in unsaturated monocarboxylic acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in very long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
Cellular Component GO Annotation Evidence Reference Source
located in peroxisome IDA
IDA: Inferred from direct assay
16141203 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT4 Protein Structure

Bile_Hydr_Trans

Bile_Hydr_Trans: Acyl-CoA thioester hydrolase/BAAT N-terminal region (16 - 141)

BAAT_C

BAAT_C: BAAT / Acyl-CoA thioester hydrolase C terminal (203 - 411)

  • 0
  • 100
  • 200
  • 300
  • 421 a.a.
Protein Preferred Names Protein Names

peroxisomal succinyl-coenzyme A thioesterase

PTE-2b

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00178 ACOT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29504 Acot4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ACOT4 RGD RGD:1596753
Mus musculus ACOT4 MGD MGI:2159621
Canis familiaris ACOT4 VGNC VGNC:49744