Calca - calcitonin/calcitonin-related polypeptide, alpha Gene

Also Known as CA; Ct; Ctn; Calc; Cgrp; CGRP1; Calc1; CGRP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12310

Summary

This gene encodes the peptide hormones Calcitonin, Calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either Calcitonin or CGRP preproproteins. Post-translational processing of the Calcitonin and CGRP propeptides results in either Calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]

Calca Products (4)

mRNA Protein Name
NM_001033954.3 NP_001029126.1 calcitonin gene-related peptide 1 isoform Cgrp preproprotein
NM_001289444.1 NP_001276373.1 calcitonin gene-related peptide 1 isoform Cgrp preproprotein
NM_001305616.1 NP_001292545.1 calcitonin gene-related peptide 1 isoform Calca preproprotein
NM_007587.2 NP_031613.2 calcitonin gene-related peptide 1 isoform Calca preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcitonin receptor binding IDA
IDA: Inferred from direct assay
9322931 MGI
enables signaling receptor binding IDA
IDA: Inferred from direct assay
7698182 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
8582325 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
8582325 MGI
acts upstream of or within artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
11717154 MGI
acts upstream of or within cellular response to nerve growth factor stimulus IDA
IDA: Inferred from direct assay
24760869 MGI
acts upstream of or within detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
16118273 MGI
acts upstream of or within feeding behavior IDA
IDA: Inferred from direct assay
8735980 MGI
acts upstream of or within inflammatory response IDA
IDA: Inferred from direct assay
7698182 MGI
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
12488435 MGI
acts upstream of or within negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
10642343 MGI
acts upstream of or within negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
12488435 MGI
acts upstream of or within negative regulation of smooth muscle contraction IDA
IDA: Inferred from direct assay
9322931 MGI
acts upstream of or within neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
7698182 MGI
acts upstream of ossification IMP
IMP: Inferred from mutant phenotype
12488435 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
11166483 MGI
acts upstream of or within response to pain IMP
IMP: Inferred from mutant phenotype
10208559 MGI
acts upstream of smooth muscle contraction IDA
IDA: Inferred from direct assay
9322931 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
7521790 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
9271704 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
8735980 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
7955356 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
11466438 MGI
located in terminal bouton IDA
IDA: Inferred from direct assay
8453761 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcitonin gene-related peptide 1

  • alpha-type CGRP

  • calcitonin gene-related peptide I

Recombinant Calca Proteins

Cat. No. Product Name Accession Purity
HY-P77587 Calcitonin/CALCA Protein, Mouse (HEK293, Fc) Q99JA0 (V26-F119) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01828 CALCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18268 Calca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24746 Calca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Calca NCBI NCBI:796