Casp9 - caspase 9 Gene

Also Known as Mch6; APAF-3; CASP-9; ICE-LAP6; Caspase-9

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12371

About Casp9

Chromosome 4: 141,520,923-141,543,287 forward strand.GRCm39:CM000997.3

This gene has 6 transcripts (splice variants), 204 orthologues, 11 paralogues and is associated with 38 phenotypes. Ubiquitous expression in small intestine adult (RPKM 37.5), spleen adult (RPKM 32.3) and 28 other tissues.

Summary

This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and Apoptosis signaling. This protein, the initiator Caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

Casp9 Products (3)

mRNA	Protein	Name
NM_015733.5	NP_056548.2	caspase-9 isoform 1 precursor
NM_001355176.1	NP_001342105.1	caspase-9 isoform 3 precursor
NM_001277932.1	NP_001264861.1	caspase-9 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	16183742	MGI
enables peptidase activity	IDA IDA: Inferred from direct assay	14561754	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14561754	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	11092819	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	15776018	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	16469926	MGI
involved in cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	15944155	MGI
acts upstream of or within epithelial cell apoptotic process	IDA IDA: Inferred from direct assay	17901126	MGI
acts upstream of or within fibroblast apoptotic process	IDA IDA: Inferred from direct assay	12847083	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	11150333	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11092819	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	11150333	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11092819	MGI
acts upstream of or within response to UV	IMP IMP: Inferred from mutant phenotype	11092819	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	15271982	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15271982	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp9 Protein Structure

CARD_CASP9

CASc

0
100
200
300
400
454 a.a.

Protein Preferred Names	Protein Names
caspase-9	ICE-like apoptotic protease 6 apoptotic protease Mch-6 apoptotic protease-activating factor 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10135	RES-701-1	Antagonist	/	Unkown
HY-P5568	Siamycin III	Inhibitor	/	Unkown
HY-RS01969	CASP9 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01970	Casp9 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01971	Casp9 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp9	NCBI	NCBI:842