Cast - calpastatin Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12380

Summary

This gene encodes an inhibitor of the calcium-dependent cysteine protease, calpain. This protein plays roles in multiple processes, including Apoptosis, cell cycle regulation, and membrane fusion. Multiple protein isoforms exist which contain unique N-terminal domains, and multiple inhibitory domains that share homology with each Other. Some isoforms may be tissue-specific. Two different pseudogenes of this gene are found on chromosome 19. [provided by RefSeq, Jul 2014]

Cast Products (8)

mRNA Protein Name
NM_001301153.1 NP_001288082.1 calpastatin isoform 1
NM_001301155.1 NP_001288084.1 calpastatin isoform 3
NM_001301156.1 NP_001288085.1 calpastatin isoform 4
NM_001301157.1 NP_001288086.1 calpastatin isoform 5
NM_001301158.1 NP_001288087.1 calpastatin isoform 6
NM_001301160.1 NP_001288089.1 calpastatin isoform 7
NM_001301181.1 NP_001288110.1 calpastatin isoform 8
NM_009817.4 NP_033947.1 calpastatin isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of peptidase activity IGI
IGI: Inferred from genetic interaction
21849499 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
11090425 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calpastatin

  • calpain inhibitor

  • calpastatin type III

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N7055 Trierucin 99.89% Unkown
HY-186130 CAST-calpain-2 stabilizer-1 Inhibitor 99.50% Unkown
HY-N10637 N-Acetyldopamine dimer-1 / Unkown
HY-N12703 N-Acetyldopamine dimmers A / Unkown
HY-RS01978 CAST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04477 ERC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17878 Cast Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24347 Cast Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cast NCBI NCBI:831