Cfl1 - cofilin 1, non-muscle Gene

Also Known as Cof

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12631

Summary

Enables actin filament binding activity and signaling receptor binding activity. Involved in Cytoskeleton organization; positive regulation of actin filament depolymerization; and positive regulation of embryonic development. Acts upstream of or within several processes, including neural crest cell migration; neural fold formation; and response to amino acid. Located in cell-cell junction; cortical actin cytoskeleton; and lamellipodium. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and immune system. Orthologous to human CFL1 (cofilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cfl1 Products (1)

mRNA Protein Name
NM_007687.5 NP_031713.1 cofilin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
11809832 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25208553 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
24052308 MGI
Biological Process GO Annotation Evidence References Source
involved in actin filament depolymerization IDA
IDA: Inferred from direct assay
11809832 MGI
involved in actin filament fragmentation IDA
IDA: Inferred from direct assay
11809832 MGI
acts upstream of or within actin filament organization IMP
IMP: Inferred from mutant phenotype
15649475 MGI
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
25208553 MGI
acts upstream of or within cell motility IMP
IMP: Inferred from mutant phenotype
15548599 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
15649475 MGI
involved in establishment of spindle localization IMP
IMP: Inferred from mutant phenotype
25208553 MGI
acts upstream of or within mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
15548599 MGI
acts upstream of or within neural crest cell migration IMP
IMP: Inferred from mutant phenotype
15649475 MGI
acts upstream of or within neural fold formation IMP
IMP: Inferred from mutant phenotype
15649475 MGI
involved in positive regulation of actin filament depolymerization IDA
IDA: Inferred from direct assay
23921380 MGI
acts upstream of or within positive regulation of actin filament depolymerization IMP
IMP: Inferred from mutant phenotype
15548599 MGI
involved in positive regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
25208553 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
17018287 MGI
acts upstream of or within response to amino acid IDA
IDA: Inferred from direct assay
17018287 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
15004221 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15548599 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16388910 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
25107909 MGI
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
16388910 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cofilin-1

  • n-cofilin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15700 VPS72 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-125444 TH251 Inhibitor / Unkown
HY-RS02568 CFL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18607 Cfl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25093 Cfl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfl1 NCBI NCBI:1072