Chga - chromogranin A Gene

Also Known as cgA; ChrA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12652

Summary

This gene encodes a member of the granin family of acidic secretory glycoproteins that are expressed in endocrine cells and neurons. The encoded preproprotein undergoes proteolytic processing to generate multiple functions peptides including pancreastatin, catestatin and serpinin. The encoded protein plays important roles in the neuroendocrine system including regulated secretion of peptide Hormones and neurotransmitters. Mice lacking the encoded protein exhibit elevated blood pressure which can be rescued by transgenic expression of the human ortholog. [provided by RefSeq, Nov 2015]

Chga Products (1)

mRNA Protein Name
NM_007693.2 NP_031719.1 chromogranin-A preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16219686 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of dense core granule biogenesis IDA
IDA: Inferred from direct assay
21436258 MGI
acts upstream of or within protein localization to secretory granule IDA
IDA: Inferred from direct assay
16219686 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromogranin-A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02624 CHGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18918 Chga Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25408 Chga Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chga NCBI NCBI:1113