Vsx2 - visual system homeobox 2 Gene

Also Known as or; Chx10; Hox10; Hox-10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12677

Summary

This gene encodes a member of the Vsx (visual system homeobox) family which belongs to the larger PRD homeobox class. The encoded protein is required for eye organogenesis and controls retinal development. Disruption of this gene is associated with ocular retardation J (orJ), a mouse disease which causes microphthalmia, retinal degeneration and optic nerve aplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Vsx2 Products (2)

mRNA Protein Name
NM_001301427.1 NP_001288356.1 visual system homeobox 2 isoform 1
NM_007701.3 NP_031727.1 visual system homeobox 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9464541 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within camera-type eye development IGI
IGI: Inferred from genetic interaction
15576400 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
15576400 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
8630490 MGI
acts upstream of or within negative regulation of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
16384989 MGI
acts upstream of neuroblast proliferation IMP
IMP: Inferred from mutant phenotype
16384989 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
8630490 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15767664 MGI
acts upstream of or within retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
8630490 MGI
acts upstream of or within retinal bipolar neuron differentiation IMP
IMP: Inferred from mutant phenotype
8630490 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15767664 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
10482234 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15767664 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

visual system homeobox 2

  • C. elegans ceh-10 homeo domain containing homolog

  • ceh-10 homeodomain-containing homolog

  • homeobox protein CHX10

  • ocular retardation

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W009310 9-cis-Retinal 99.9% Unkown
HY-RS15719 VSX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19973 Vsx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26476 Vsx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vsx2 NCBI NCBI:338917