Cpox - coproporphyrinogen oxidase Gene

Also Known as CPX; Cpo; HCP; cac; nct; M100835; Rgsc835

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12892

Summary

Enables coproporphyrinogen oxidase activity. A structural constituent of eye lens. Acts upstream of or within heme biosynthetic process. Located in membrane and mitochondrion. Is expressed in embryo and yolk sac. Used to study hereditary coproporphyria. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Apr 2022]

Cpox Products (1)

mRNA Protein Name
NM_007757.2 NP_031783.2 oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables coproporphyrinogen oxidase activity IDA
IDA: Inferred from direct assay
7607249 MGI
enables structural constituent of eye lens IMP
IMP: Inferred from mutant phenotype
12470976 MGI
Biological Process GO Annotation Evidence References Source
involved in heme A biosynthetic process IDA
IDA: Inferred from direct assay
8407975 MGI
involved in heme B biosynthetic process IDA
IDA: Inferred from direct assay
8407975 MGI
involved in heme O biosynthetic process IDA
IDA: Inferred from direct assay
8407975 MGI
acts upstream of or within heme biosynthetic process IDA
IDA: Inferred from direct assay
8407975 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IMP
IMP: Inferred from mutant phenotype
20080761 MGI
is active in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
8407975 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
8407975 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

  • COX

  • Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX)

  • clone 560

  • coprogen oxidase

  • coproporphyrinogen-III oxidase, mitochondrial

  • coproporphyrinogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03112 CPOX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20261 Cpox Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26769 Cpox Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cpox NCBI NCBI:1371