Cttn - cortactin Gene

Also Known as Ems1; 1110020L01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13043

Summary

Predicted to enable several functions, including Arp2/3 complex binding activity; actin filament binding activity; and profilin binding activity. Involved in intracellular protein transport and regulation of Autophagy of mitochondrion. Acts upstream of or within dendritic spine maintenance; negative regulation of extrinsic apoptotic signaling pathway; and substrate-dependent cell migration, cell extension. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including 1-cell stage conceptus; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CTTN (cortactin). [provided by Alliance of Genome Resources, Apr 2022]

Cttn Products (3)

mRNA Protein Name
NM_001252572.2 NP_001239501.1 src substrate cortactin isoform 2
NM_001357116.2 NP_001344045.1 src substrate cortactin isoform 3
NM_007803.6 NP_031829.2 src substrate cortactin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11018051 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within dendritic spine maintenance IGI
IGI: Inferred from genetic interaction
23365224 MGI
acts upstream of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
22660580 MGI
involved in intracellular protein transport IMP
IMP: Inferred from mutant phenotype
17959782 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
22660580 MGI
involved in regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
20457763 MGI
acts upstream of or within substrate-dependent cell migration, cell extension IGI
IGI: Inferred from genetic interaction
19414610 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
12913069 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12913069 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
12853475 MGI
located in mitotic spindle midzone IDA
IDA: Inferred from direct assay
22282019 MGI
located in podosome IDA
IDA: Inferred from direct assay
17893324 MGI
located in ruffle IDA
IDA: Inferred from direct assay
10637315 MGI
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
17959782 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

src substrate cortactin

  • mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03350 CTTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22133 Cttn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28655 Cttn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cttn NCBI NCBI:2017